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| Columbia Lions vs Fordham Rams | Tuesday, November 9, 2021 | 7:00 PM EST | Rose Hill Gymnasium in Bronx, NY | ESPN+ |
| Marist Red Foxes vs Columbia Lions | Saturday, November 13, 2021 | 7:00 PM EST | Francis S. Levien Gymnasium in New York, NY | ESPN+ |
| Binghamton Bearcats vs Columbia Lions | Wednesday, November 17, 2021 | 7:00 PM EST | Francis S. Levien Gymnasium in New York, NY | ESPN+ |
| Columbia Lions vs Lehigh Mountain Hawks | Tuesday, November 23, 2021 | 7:00 PM EST | Stabler Arena in Bethlehem, PA | ESPN+ |
| Columbia Lions vs Boston College Eagles | Friday, November 26, 2021 | 7:00 PM EST | Silvio O. Conte Forum in Chestnut Hill, MA | ESPN+ |
| Lafayette Leopards vs Columbia Lions | Monday, November 29, 2021 | 7:00 PM EST | Francis S. Levien Gymnasium in New York, NY | ESPN+ |
| Columbia Lions vs UMBC Retrievers | Thursday, December 2, 2021 | 7:00 PM EST | UMBC Event Center in Baltimore, MD | ESPN+ |
| Columbia Lions vs Colgate Raiders | Tuesday, December 7, 2021 | 7:00 PM EST | Cotterell Court in Hamilton, NY | ESPN+ |
| Columbia Lions vs Albany Great Danes | Saturday, December 11, 2021 | 7:00 PM EST | SEFCU Arena in Albany, NY | ESPN+ |
| Sacred Heart Pioneers vs Columbia Lions | Monday, December 13, 2021 | 7:00 PM EST | Francis S. Levien Gymnasium in New York, NY | ESPN+ |
| Columbia Lions vs Yale Bulldogs | Sunday, January 2, 2022 | 7:00 PM EST | John J. Lee Amphitheater in New Haven, CT | ESPN+ |
| Columbia Lions vs Princeton Tigers | Friday, January 7, 2022 | 7:00 PM EST | Jadwin Gymnasium in Princeton, NJ | ESPN+ |
| Columbia Lions vs Penn Quakers | Saturday, January 8, 2022 | 7:00 PM EST | The Palestra in Philadelphia, PA | ESPN+ |
| Harvard Crimson vs Columbia Lions | Saturday, January 15, 2022 | 7:00 PM EST | Francis S. Levien Gymnasium in New York, NY | ESPN+ |
| Columbia Lions vs Cornell Big Red | Monday, January 17, 2022 | 7:00 PM EST | Newman Arena in Ithaca, NY | ESPN+ |
| Brown Bears vs Columbia Lions | Saturday, January 22, 2022 | 7:00 PM EST | Francis S. Levien Gymnasium in New York, NY | ESPN+ |
| Penn Quakers vs Columbia Lions | Friday, February 4, 2022 | 7:00 PM EST | Francis S. Levien Gymnasium in New York, NY | ESPN+ |
| Princeton Tigers vs Columbia Lions | Saturday, February 5, 2022 | 7:00 PM EST | Francis S. Levien Gymnasium in New York, NY | ESPN+ |
| Yale Bulldogs vs Columbia Lions | Saturday, February 12, 2022 | 7:00 PM EST | Francis S. Levien Gymnasium in New York, NY | ESPN+ |
| Columbia Lions vs Dartmouth Big Green | Saturday, February 19, 2022 | 7:00 PM EST | Edward Leede Arena in Hanover, NH | ESPN+ |
| Columbia Lions vs Harvard Crimson | Saturday, February 19, 2022 | 7:00 PM EST | Lavietes Pavilion in Cambridge, MA | ESPN+ |
| Columbia Lions vs Brown Bears | Saturday, February 26, 2022 | 7:00 PM EST | Pizzitola Sports Center in Providence, RI | ESPN+ |
