| Louisville Cardinals vs Ole Miss Rebels |
Monday, September 6, 2021 |
8:00 PM EST |
Mercedes-Benz Stadium in Atlanta, GA |
ESPN |
| UCF Knights vs Louisville Cardinals |
Friday, September 17, 2021 |
7:30 PM EST |
Cardinal Stadium in Louisville, KY |
ESPN |
| Louisville Cardinals vs Florida State Seminoles |
Saturday, September 25, 2021 |
3:30 PM EST |
Doak Campbell Stadium in Tallahassee, FL |
ESPN2 |
| Louisville Cardinals vs Wake Forest Demon Deacons |
Saturday, October 2, 2021 |
12:30 PM EST |
Truist Field in Winston-Salem, NC |
ESPN3 |
| Virginia Cavaliers vs Louisville Cardinals |
Saturday, October 9, 2021 |
1:00 PM EST |
Cardinal Stadium in Louisville, KY |
ABC/ESPN2/ACCN |
| Boston College Eagles vs Louisville Cardinals |
Saturday, October 23, 2021 |
4:00 PM EST |
Cardinal Stadium in Louisville, KY |
ACCN |
| Louisville Cardinals vs NC State Wolfpack |
Saturday, October 30, 2021 |
7:30 PM EST |
Carter-Finley Stadium in Raleigh, NC |
ACCN |
| Clemson Tigers vs Louisville Cardinals |
Saturday, November 6, 2021 |
7:30 PM EST |
Cardinal Stadium in Louisville, KY |
ACCN |
| Syracuse Orange vs Louisville Cardinals |
Saturday, November 13, 2021 |
12:00 PM EST |
Cardinal Stadium in Louisville, KY |
ESPN3 |
| Louisville Cardinals vs Duke Blue Devils |
Thursday, November 18, 2021 |
7:30 PM EST |
Wallace Wade Stadium in Durham, NC |
ESPN |
| Kentucky Wildcats vs Louisville Cardinals |
Saturday, November 27, 2021 |
7:30 PM EST |
Cardinal Stadium in Louisville, KY |
ESPN2 |
