| Game | Date | Time | Stadium | TV Station |
|---|---|---|---|---|
| Louisville Cardinals vs Syracuse Orange | Saturday, September 3, 2022 | 8:00 PM EST | JMA Wireless Dome in Syracuse, NY | ACCN |
| Louisville Cardinals vs UCF Knights | Friday, September 9, 2022 | 7:30 PM EST | Bounce House in Orlando, FL | ESPN2 |
| Florida State Seminoles vs Louisville Cardinals | Friday, September 16, 2022 | 7:30 PM EST | Cardinal Stadium in Louisville, KY | ESPN |
| USF Bulls vs Louisville Cardinals | Saturday, September 24, 2022 | 12:00 PM EST | Cardinal Stadium in Louisville, KY | ESPN+ |
| Louisville Cardinals vs Boston College Eagles | Saturday, October 1, 2022 | 12:00 PM EST | Alumni Stadium in Chestnut Hill, MA | ESPN+ |
| Louisville Cardinals vs Virginia Cavaliers | Saturday, October 8, 2022 | 12:00 PM EST | Scott Stadium in Charlottesville, VA | ESPN+ |
| Pittsburgh Panthers vs Louisville Cardinals | Saturday, October 22, 2022 | 12:00 PM EST | Cardinal Stadium in Louisville, KY | ESPN+ |
| Wake Forest Demon Deacons vs Louisville Cardinals | Saturday, October 29, 2022 | 12:00 PM EST | Cardinal Stadium in Louisville, KY | ESPN+ |
| James Madison Dukes vs Louisville Cardinals | Saturday, November 5, 2022 | 12:00 PM EST | Cardinal Stadium in Louisville, KY | ESPN+ |
| Louisville Cardinals vs Clemson Tigers | Saturday, November 12, 2022 | 12:00 PM EST | Memorial Stadium in Clemson, SC | ESPN+ |
| NC State Wolfpack vs Louisville Cardinals | Saturday, November 19, 2022 | 12:00 PM EST | Cardinal Stadium in Louisville, KY | ESPN+ |
| Louisville Cardinals vs Kentucky Wildcats | Saturday, November 26, 2022 | 12:00 PM EST | Kroger Field in Lexington, KY | ESPN+ |
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2021 Louisville Cardinals TV Broadcast Schedule
| Game | Date | Time | Stadium | TV Station |
|---|---|---|---|---|
| Louisville Cardinals vs Ole Miss Rebels | Monday, September 6, 2021 | 8:00 PM EST | Mercedes-Benz Stadium in Atlanta, GA | ESPN |
| UCF Knights vs Louisville Cardinals | Friday, September 17, 2021 | 7:30 PM EST | Cardinal Stadium in Louisville, KY | ESPN |
| Louisville Cardinals vs Florida State Seminoles | Saturday, September 25, 2021 | 3:30 PM EST | Doak Campbell Stadium in Tallahassee, FL | ESPN2 |
| Louisville Cardinals vs Wake Forest Demon Deacons | Saturday, October 2, 2021 | 12:30 PM EST | Truist Field in Winston-Salem, NC | ESPN3 |
| Virginia Cavaliers vs Louisville Cardinals | Saturday, October 9, 2021 | 1:00 PM EST | Cardinal Stadium in Louisville, KY | ABC/ESPN2/ACCN |
| Boston College Eagles vs Louisville Cardinals | Saturday, October 23, 2021 | 4:00 PM EST | Cardinal Stadium in Louisville, KY | ACCN |
| Louisville Cardinals vs NC State Wolfpack | Saturday, October 30, 2021 | 7:30 PM EST | Carter-Finley Stadium in Raleigh, NC | ACCN |
| Clemson Tigers vs Louisville Cardinals | Saturday, November 6, 2021 | 7:30 PM EST | Cardinal Stadium in Louisville, KY | ACCN |
| Syracuse Orange vs Louisville Cardinals | Saturday, November 13, 2021 | 12:00 PM EST | Cardinal Stadium in Louisville, KY | ESPN3 |
| Louisville Cardinals vs Duke Blue Devils | Thursday, November 18, 2021 | 7:30 PM EST | Wallace Wade Stadium in Durham, NC | ESPN |
| Kentucky Wildcats vs Louisville Cardinals | Saturday, November 27, 2021 | 7:30 PM EST | Cardinal Stadium in Louisville, KY | ESPN2 |
