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| Tennessee Tech Golden Eagles vs Memphis Tigers | Tuesday, November 9, 2021 | 6:30 PM EST | FedExForum in Memphis, TN | ESPN+ |
| North Carolina Central Eagles vs Memphis Tigers | Saturday, November 13, 2021 | 7:00 PM EST | FedExForum in Memphis, TN | ESPN+ |
| Saint Louis Billikens vs Memphis Tigers | Tuesday, November 16, 2021 | 6:30 PM EST | FedExForum in Memphis, TN | ESPN+ |
| Western Kentucky Hilltoppers vs Memphis Tigers | Friday, November 19, 2021 | 7:00 PM EST | FedExForum in Memphis, TN | ESPN+ |
| Memphis Tigers vs Virginia Tech Hokies | Thursday, November 25, 2021 | 9:30 PM EST | Barclays Center in Brooklyn, NY | ESPN2 |
| Memphis Tigers vs Georgia Bulldogs | Thursday, December 2, 2021 | 7:30 PM EST | Stegeman Coliseum in Athens, GA | SEC Network |
| Murray State Racers vs Memphis Tigers | Friday, December 10, 2021 | 7:00 PM EST | FedExForum in Memphis, TN | ESPN+ |
| Alabama Crimson Tide vs Memphis Tigers | Wednesday, December 15, 2021 | 9:00 PM EST | FedExForum in Memphis, TN | ESPN2 |
| Tennessee Volunteers vs Memphis Tigers | Saturday, December 18, 2021 | 12:00 PM EST | Bridgestone Arena in Nashville, TN | ESPN+ |
| Alabama State Hornets vs Memphis Tigers | Tuesday, December 21, 2021 | 7:00 PM EST | FedExForum in Memphis, TN | ESPN+ |
| Memphis Tigers vs Tulane Green Wave | Wednesday, December 29, 2021 | 7:00 PM EST | Avron B. Fogelman Arena in the Devlin Fieldhouse in New Orleans, LA | ESPN+ |
| Tulsa Golden Hurricane vs Memphis Tigers | Wednesday, January 5, 2022 | 9:00 PM EST | FedExForum in Memphis, TN | ESPNU |
| Cincinnati Bearcats vs Memphis Tigers | Sunday, January 9, 2022 | 3:30 PM EST | FedExForum in Memphis, TN | ABC |
| Memphis Tigers vs UCF Knights | Wednesday, January 12, 2022 | 7:00 PM EST | Addition Financial Arena in Orlando, FL | ESPN+ |
| Memphis Tigers vs East Carolina Pirates | Saturday, January 15, 2022 | 7:00 PM EST | Williams Arena at Minges Coliseum in Greenville, NC | ESPN+ |
| SMU Mustangs vs Memphis Tigers | Friday, January 21, 2022 | 7:00 PM EST | FedExForum in Memphis, TN | ESPN2 |
| Memphis Tigers vs Tulsa Golden Hurricane | Sunday, January 23, 2022 | 3:00 PM EST | Donald W. Reynolds Center in Tulsa, OK | ESPN |
| East Carolina Pirates vs Memphis Tigers | Friday, January 28, 2022 | 9:00 PM EST | FedExForum in Memphis, TN | ESPN2 |
| Memphis Tigers vs Cincinnati Bearcats | Friday, February 4, 2022 | 7:00 PM EST | Fifth Third Arena in Cincinnati, OH | ESPN2 |
| UCF Knights vs Memphis Tigers | Sunday, February 6, 2022 | 8:00 PM EST | FedExForum in Memphis, TN | ESPN+ |
| Tulane Green Wave vs Memphis Tigers | Wednesday, February 9, 2022 | 7:00 PM EST | FedExForum in Memphis, TN | ESPN+ |
| Memphis Tigers vs Houston Cougars | Saturday, February 12, 2022 | 3:30 PM EST | Fertitta Center in Houston, TX | ABC |
| Memphis Tigers vs SMU Mustangs | Sunday, February 20, 2022 | 3:00 PM EST | Moody Coliseum in Dallas, TX | ESPN |
| Temple Owls vs Memphis Tigers | Friday, February 25, 2022 | 7:00 PM EST | FedExForum in Memphis, TN | ESPN2 |
| Memphis Tigers vs USF Bulls | Thursday, March 3, 2022 | 7:00 PM EST | Yuengling Center in Tampa, FL | ESPN+ |
