| Michigan State Spartans vs Northwestern Wildcats |
Friday, September 3, 2021 |
9:00 PM EST |
Ryan Field in Evanston, IL |
ESPN |
| Michigan State Spartans vs Miami Hurricanes |
Saturday, September 18, 2021 |
12:00 PM EST |
Hard Rock Stadium in Miami Gardens, FL |
ESPN+ |
| Nebraska Cornhuskers vs Michigan State Spartans |
Saturday, September 25, 2021 |
7:00 PM EST |
Spartan Stadium in East Lansing, MI |
FS1 |
| Western Kentucky Hilltoppers vs Michigan State Spartans |
Saturday, October 2, 2021 |
7:30 PM EST |
Spartan Stadium in East Lansing, MI |
FS1 |
| Michigan State Spartans vs Rutgers Scarlet Knights |
Saturday, October 9, 2021 |
1:00 PM EST |
SHI Stadium in Piscataway, NJ |
BTN |
| Michigan State Spartans vs Indiana Hoosiers |
Saturday, October 16, 2021 |
12:00 PM EST |
Memorial Stadium in Champaign, IL |
FS1 |
| Michigan Wolverines vs Michigan State Spartans |
Saturday, October 30, 2021 |
12:00 PM EST |
Spartan Stadium in East Lansing, MI |
FOX |
| Michigan State Spartans vs Purdue Boilermakers |
Saturday, November 6, 2021 |
3:30 PM EST |
Ross-Ade Stadium in West Lafayette, IN |
ABC |
| Maryland Terrapins vs Michigan State Spartans |
Saturday, November 13, 2021 |
4:00 PM EST |
Spartan Stadium in East Lansing, MI |
FOX |
| Michigan State Spartans vs Ohio State Buckeyes |
Saturday, November 20, 2021 |
12:00 PM EST |
Ohio Stadium in Columbus, OH |
ABC |
| Penn State Nittany Lions vs Michigan State Spartans |
Saturday, November 27, 2021 |
3:30 PM EST |
Spartan Stadium in East Lansing, MI |
ABC |
