Santana has a batting average of .255 for his time in baseball with 233 runs scored and an OPS of .301. In his time spent in pro baseball, he stepped up to bat 1,919 times and has delivered with a hit 428 times. His slugging percentage is -.040 in addition to racking up 750 bases. In his career, Santana has hit 77 baseballs out of the park while knocking in 244 runs. He has fanned 612 times and has taken a walk on 209 at-bats, which has contributed to a .341 on-base percentage.