|
| Appalachian State Mountaineers vs Iona Gaels | Tuesday, November 9, 2021 | 7:00 PM EST | Hynes Athletics Center in New Rochelle, NY | ESPN+ |
| Charlotte 49ers vs Appalachian State Mountaineers | Thursday, November 18, 2021 | 7:00 PM EST | Holmes Convocation Center in Boone, NC | ESPN+ |
| Appalachian State Mountaineers vs Delaware Blue Hens | Tuesday, November 23, 2021 | 7:30 PM EST | Hertz Arena in Estero, FL | ESPN+ |
| Hartford Hawks vs Appalachian State Mountaineers | Monday, November 29, 2021 | 7:00 PM EST | Holmes Convocation Center in Boone, NC | ESPN+ |
| Appalachian State Mountaineers vs Furman Paladins | Friday, December 10, 2021 | 7:00 PM EST | Timmons Arena in Greenville, SC | ESPN+ |
| Appalachian State Mountaineers vs North Carolina Tar Heels | Wednesday, December 22, 2021 | 7:00 PM EST | Dean E. Smith Center in Chapel Hill, NC | ACC Network |
| Louisiana Ragin’ Cajuns vs Appalachian State Mountaineers | Thursday, December 30, 2021 | 7:00 PM EST | Holmes Convocation Center in Boone, NC | ESPN+ |
| Appalachian State Mountaineers vs South Alabama Jaguars | Friday, January 7, 2022 | 8:00 PM EST | Mitchell Center in Mobile, AL | ESPN+ |
| Appalachian State Mountaineers vs Troy Trojans | Saturday, January 8, 2022 | 7:00 PM EST | Trojan Arena in Troy, AL | ESPN+ |
| Coastal Carolina Chanticleers vs Appalachian State Mountaineers | Thursday, January 13, 2022 | 7:00 PM EST | Holmes Convocation Center in Boone, NC | ESPN+ |
| Appalachian State Mountaineers vs Coastal Carolina Chanticleers | Saturday, January 15, 2022 | 2:00 PM EST | The HTC Center in Conway, SC | ESPN+ |
| Appalachian State Mountaineers vs Georgia State Panthers | Friday, January 21, 2022 | 7:00 PM EST | GSU Sports Arena in Atlanta, GA | ESPN+ |
| Appalachian State Mountaineers vs Georgia Southern Eagles | Saturday, January 22, 2022 | 7:00 PM EST | W.S. Hanner Fieldhouse in Statesboro, GA | ESPN+ |
| Arkansas State Red Wolves vs Appalachian State Mountaineers | Thursday, January 27, 2022 | 7:00 PM EST | Holmes Convocation Center in Boone, NC | ESPN+ |
| Appalachian State Mountaineers vs Texas State Bobcats | Thursday, February 3, 2022 | 7:00 PM EST | Strahan Arena at the University Events Center in San Marcos, TX | ESPN+ |
| Appalachian State Mountaineers vs UT Arlington Mavericks | Saturday, February 5, 2022 | 7:00 PM EST | College Park Center in Arlington, TX | ESPN+ |
| Georgia State Panthers vs Appalachian State Mountaineers | Saturday, February 12, 2022 | 7:00 PM EST | Holmes Convocation Center in Boone, NC | ESPN+ |
| South Alabama Jaguars vs Appalachian State Mountaineers | Saturday, February 19, 2022 | 7:00 PM EST | Holmes Convocation Center in Boone, NC | ESPN+ |
| Appalachian State Mountaineers vs Little Rock Trojans | Thursday, February 24, 2022 | 7:00 PM EST | Jack Stephens Center in Little Rock, AR | ESPN+ |
| Appalachian State Mountaineers vs Arkansas State Red Wolves | Saturday, February 26, 2022 | 7:00 PM EST | First National Bank Arena in Jonesboro, AR | ESPN+ |
