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| Northern Arizona Lumberjacks vs Arizona Wildcats | Wednesday, November 10, 2021 | 10:30 PM EST | McKale Center in Tucson, AZ | PAC12 |
| UTRGV Vaqueros vs Arizona Wildcats | Saturday, November 13, 2021 | 9:00 PM EST | McKale Center in Tucson, AZ | PAC12 |
| North Dakota State Bison vs Arizona Wildcats | Wednesday, November 17, 2021 | 9:00 PM EST | McKale Center in Tucson, AZ | PAC12 |
| Wichita State Shockers vs Arizona Wildcats | Saturday, November 20, 2021 | 10:00 PM EST | T-Mobile Arena in Las Vegas, NV | ESPNU |
| Sacramento State Hornets vs Arizona Wildcats | Saturday, November 27, 2021 | 7:00 PM EST | McKale Center in Tucson, AZ | PAC12 |
| Washington Huskies vs Arizona Wildcats | Friday, December 3, 2021 | 8:30 PM EST | McKale Center in Tucson, AZ | PAC12 |
| Arizona Wildcats vs Oregon State Beavers | Sunday, December 5, 2021 | 4:00 PM EST | Gill Coliseum in Corvallis, OR | ESPNU |
| Wyoming Cowboys vs Arizona Wildcats | Thursday, December 9, 2021 | 10:00 PM EST | McKale Center in Tucson, AZ | PAC12 |
| Arizona Wildcats vs Illinois Fighting Illini | Saturday, December 11, 2021 | 5:00 PM EST | State Farm Center in Champaign, IL | FOX |
| Northern Colorado Bears vs Arizona Wildcats | Thursday, December 16, 2021 | 9:00 PM EST | McKale Center in Tucson, AZ | PAC12 |
| California Baptist Lancers vs Arizona Wildcats | Saturday, December 18, 2021 | 6:00 PM EST | McKale Center in Tucson, AZ | PAC12 |
| Arizona Wildcats vs Tennessee Volunteers | Thursday, December 23, 2021 | 7:00 PM EST | Thompson-Boling Arena in Knoxville, TN | ESPN2 |
| Arizona Wildcats vs UCLA Bruins | Friday, December 31, 2021 | 9:00 PM EST | Pauley Pavilion presented by Wescom in Los Angeles, CA | ESPN2 |
| Arizona Wildcats vs USC Trojans | Sunday, January 2, 2022 | 5:00 PM EST | Galen Center in Los Angeles, CA | ESPN+ |
| Arizona Wildcats vs Arizona State Sun Devils | Saturday, January 8, 2022 | 7:00 PM EST | Desert Financial Arena in Tempe, AZ | FS1 |
| Colorado Buffaloes vs Arizona Wildcats | Friday, January 14, 2022 | 11:00 PM EST | McKale Center in Tucson, AZ | FS1 |
| Utah Utes vs Arizona Wildcats | Sunday, January 16, 2022 | 8:00 PM EST | McKale Center in Tucson, AZ | PAC12 |
| Arizona Wildcats vs Stanford Cardinal | Friday, January 21, 2022 | 11:00 PM EST | Maples Pavilion in Stanford, CA | ESPNU |
| Arizona Wildcats vs California Golden Bears | Sunday, January 23, 2022 | 3:00 PM EST | Haas Pavilion in Berkeley, CA | PAC12 |
| UCLA Bruins vs Arizona Wildcats | Friday, February 4, 2022 | 8:00 PM EST | McKale Center in Tucson, AZ | ESPN |
| USC Trojans vs Arizona Wildcats | Saturday, February 5, 2022 | 5:00 PM EST | McKale Center in Tucson, AZ | FOX |
| Arizona Wildcats vs Washington Huskies | Saturday, February 12, 2022 | 6:00 PM EST | Alaska Airlines Arena in Seattle, WA | PAC12 |
| Oregon Ducks vs Arizona Wildcats | Sunday, February 20, 2022 | 10:00 PM EST | McKale Center in Tucson, AZ | ESPN+ |
| Arizona Wildcats vs Utah Utes | Friday, February 25, 2022 | 11:00 PM EST | Jon M. Huntsman Center in Salt Lake City, UT | FS1 |
| Arizona Wildcats vs Colorado Buffaloes | Sunday, February 27, 2022 | 8:00 PM EST | CU Events Center in Boulder, CO | ESPN+ |
| Stanford Cardinal vs Arizona Wildcats | Friday, March 4, 2022 | 9:00 PM EST | McKale Center in Tucson, AZ | ESPN+ |
