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| Bellarmine Knights vs Purdue Boilermakers | Wednesday, November 10, 2021 | 9:00 PM EST | Mackey Arena in West Lafayette, IN | ESPN+ |
| Bellarmine Knights vs Murray State Racers | Sunday, November 14, 2021 | 8:00 PM EST | CFSB Center in Murray, KY | ESPN+ |
| Bellarmine Knights vs St. Mary’s Gaels | Thursday, November 18, 2021 | 10:00 PM EST | University Credit Union Pavilion in Moraga, CA | ESPN+ |
| Bellarmine Knights vs Gonzaga Bulldogs | Friday, November 19, 2021 | 7:00 PM EST | McCarthey Athletic Center in Spokane, WA | ESPN+ |
| UCLA Bruins vs Bellarmine Knights | Tuesday, November 23, 2021 | 8:30 PM EST | T-Mobile Arena in Las Vegas, NV | ESPN+ |
| Central Michigan Chippewas vs Bellarmine Knights | Wednesday, November 24, 2021 | 7:00 PM EST | T-Mobile Arena in Las Vegas, NV | ESPN+ |
| Bellarmine Knights vs West Virginia Mountaineers | Tuesday, November 30, 2021 | 7:00 PM EST | WVU Coliseum in Morgantown, WV | ESPN+ |
| Bellarmine Knights vs South Dakota Coyotes | Thursday, December 16, 2021 | 8:00 PM EST | Sanford Coyote Sports Center in Vermillion, SD | ESPN+ |
| Bellarmine Knights vs Miami RedHawks | Saturday, December 18, 2021 | 7:00 PM EST | Millett Hall in Oxford, OH | ESPN+ |
| Loyola Marymount Lions vs Bellarmine Knights | Wednesday, December 22, 2021 | 7:00 PM EST | Freedom Hall in Louisville, KY | ESPN+ |
| Bellarmine Knights vs Bradley Braves | Thursday, December 30, 2021 | 8:00 PM EST | Carver Arena in Peoria, IL | ESPN+ |
| Bellarmine Knights vs Jacksonville State Gamecocks | Tuesday, January 4, 2022 | 7:00 PM EST | Pete Mathews Coliseum in Jacksonville, AL | ESPN+ |
| Eastern Kentucky Colonels vs Bellarmine Knights | Saturday, January 8, 2022 | 7:00 PM EST | Freedom Hall in Louisville, KY | ESPN+ |
| Central Arkansas Bears vs Bellarmine Knights | Tuesday, January 11, 2022 | 7:00 PM EST | Freedom Hall in Louisville, KY | ESPN+ |
| Bellarmine Knights vs Lipscomb Bisons | Saturday, January 15, 2022 | 7:00 PM EST | Allen Arena in Nashville, TN | ESPN+ |
| North Alabama Lions vs Bellarmine Knights | Tuesday, January 18, 2022 | 7:00 PM EST | Freedom Hall in Louisville, KY | ESPN+ |
| Jacksonville Dolphins vs Bellarmine Knights | Saturday, January 22, 2022 | 7:00 PM EST | Freedom Hall in Louisville, KY | ESPN+ |
| Bellarmine Knights vs Stetson Hatters | Thursday, January 27, 2022 | 7:00 PM EST | Edmunds Center in Deland, FL | ESPN+ |
| Liberty Flames vs Bellarmine Knights | Thursday, February 3, 2022 | 7:00 PM EST | Freedom Hall in Louisville, KY | ESPN+ |
| Kennesaw State Owls vs Bellarmine Knights | Saturday, February 5, 2022 | 7:00 PM EST | Freedom Hall in Louisville, KY | ESPN+ |
| Bellarmine Knights vs North Florida Ospreys | Wednesday, February 9, 2022 | 7:00 PM EST | UNF Arena in Jacksonville, FL | ESPN+ |
| Bellarmine Knights vs North Alabama Lions | Saturday, February 12, 2022 | 7:00 PM EST | Flowers Hall in Florence, AL | ESPN+ |
| Jacksonville State Gamecocks vs Bellarmine Knights | Saturday, February 19, 2022 | 7:00 PM EST | Freedom Hall in Louisville, KY | ESPN+ |
| Lipscomb Bisons vs Bellarmine Knights | Wednesday, February 23, 2022 | 7:00 PM EST | Freedom Hall in Louisville, KY | ESPN+ |
| Bellarmine Knights vs Eastern Kentucky Colonels | Saturday, February 26, 2022 | 7:00 PM EST | McBrayer Arena in Richmond, KY | ESPN+ |
