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| Bethune-Cookman Wildcats vs USF Bulls | Tuesday, November 9, 2021 | 4:00 PM EST | Yuengling Center in Tampa, FL | ESPN+ |
| Bethune-Cookman Wildcats vs MTSU Blue Raiders | Friday, November 12, 2021 | 7:00 PM EST | Murphy Center in Murfreesboro, TN | ESPN+ |
| Bethune-Cookman Wildcats vs Utah Utes | Tuesday, November 16, 2021 | 10:00 PM EST | Jon M. Huntsman Center in Salt Lake City, UT | PAC12 |
| Liberty Flames vs Bethune-Cookman Wildcats | Tuesday, November 23, 2021 | 5:00 PM EST | Moore Gymnasium (Daytona Beach, FL) in Daytona Beach, FL | ESPN+ |
| Bethune-Cookman Wildcats vs Seton Hall Pirates | Sunday, November 28, 2021 | 12:00 PM EST | Prudential Center in Newark, NJ | FS1 |
| Bethune-Cookman Wildcats vs UCF Knights | Sunday, December 5, 2021 | 2:00 PM EST | Addition Financial Arena in Orlando, FL | ESPN+ |
| Bethune-Cookman Wildcats vs NC State Wolfpack | Thursday, December 9, 2021 | 6:30 PM EST | PNC Arena in Raleigh, NC | ESPN+ |
| Bethune-Cookman Wildcats vs FIU Panthers | Sunday, December 19, 2021 | 1:00 PM EST | Ocean Bank Convocation Center in Miami, FL | ESPN+ |
| Bethune-Cookman Wildcats vs Marist Red Foxes | Thursday, December 23, 2021 | 7:00 PM EST | McCann Arena in Poughkeepsie, NY | ESPN+ |
| Florida A&M Rattlers vs Bethune-Cookman Wildcats | Monday, January 3, 2022 | 7:00 PM EST | Moore Gymnasium (Daytona Beach, FL) in Daytona Beach, FL | ESPN+ |
| Grambling Tigers vs Bethune-Cookman Wildcats | Saturday, January 8, 2022 | 6:30 PM EST | Moore Gymnasium (Daytona Beach, FL) in Daytona Beach, FL | ESPN+ |
| Southern Jaguars vs Bethune-Cookman Wildcats | Monday, January 10, 2022 | 7:00 PM EST | Moore Gymnasium (Daytona Beach, FL) in Daytona Beach, FL | ESPN+ |
| Bethune-Cookman Wildcats vs MVSU Delta Devils | Saturday, January 15, 2022 | 5:30 PM EST | Robert W. Harrison HPER Complex in Itta Bena, MS | ESPN+ |
| Bethune-Cookman Wildcats vs Arkansas-Pine Bluff Golden Lions | Monday, January 17, 2022 | 7:00 PM EST | H. O. Clemmons Arena in Pine Bluff, AR | ESPN+ |
| Jackson State Tigers vs Bethune-Cookman Wildcats | Saturday, January 22, 2022 | 7:00 PM EST | Moore Gymnasium (Daytona Beach, FL) in Daytona Beach, FL | ESPN+ |
| Alcorn State Braves vs Bethune-Cookman Wildcats | Monday, January 24, 2022 | 7:00 PM EST | Moore Gymnasium (Daytona Beach, FL) in Daytona Beach, FL | ESPN+ |
| Bethune-Cookman Wildcats vs Alabama A&M Bulldogs | Monday, January 31, 2022 | 6:00 PM EST | T.M. Elmore Gymnasium in Normal, AL | ESPN+ |
| Prairie View A&M Panthers vs Bethune-Cookman Wildcats | Saturday, February 5, 2022 | 1:00 PM EST | Moore Gymnasium (Daytona Beach, FL) in Daytona Beach, FL | ESPN+ |
| Texas Southern Tigers vs Bethune-Cookman Wildcats | Monday, February 7, 2022 | 7:00 PM EST | Moore Gymnasium (Daytona Beach, FL) in Daytona Beach, FL | ESPN+ |
| Bethune-Cookman Wildcats vs Alcorn State Braves | Saturday, February 12, 2022 | 7:00 PM EST | Davey L. Whitney Complex in Lorman, MS | ESPN+ |
| Bethune-Cookman Wildcats vs Jackson State Tigers | Tuesday, February 15, 2022 | 7:30 PM EST | Lee E. Williams Athletic and Assembly Center in Jackson, MS | ESPN+ |
| Alabama A&M Bulldogs vs Bethune-Cookman Wildcats | Saturday, February 19, 2022 | 7:00 PM EST | Moore Gymnasium (Daytona Beach, FL) in Daytona Beach, FL | ESPN+ |
| Alabama State Hornets vs Bethune-Cookman Wildcats | Monday, February 21, 2022 | 7:00 PM EST | Moore Gymnasium (Daytona Beach, FL) in Daytona Beach, FL | ESPN+ |
| Bethune-Cookman Wildcats vs Southern Jaguars | Saturday, February 26, 2022 | 7:00 PM EST | F. G. Clark Activity Center in Baton Rouge, LA | ESPN+ |
