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| North Dakota State Bison vs Cal Poly Mustangs | Friday, November 12, 2021 | 5:00 PM EST | Robert A. Mott Athletics Center in San Luis Obispo, CA | ESPN+ |
| Sacramento State Hornets vs Cal Poly Mustangs | Tuesday, November 16, 2021 | 10:00 PM EST | Robert A. Mott Athletics Center in San Luis Obispo, CA | ESPN+ |
| Cal Poly Mustangs vs California Baptist Lancers | Friday, December 3, 2021 | 10:00 PM EST | CBU Events Center in Riverside, CA | ESPN+ |
| Cal Poly Mustangs vs Portland State Vikings | Sunday, December 12, 2021 | 10:00 PM EST | Viking Pavilion in Portland, OR | ESPN+ |
| Cal Poly Mustangs vs Portland Pilots | Tuesday, December 14, 2021 | 10:00 PM EST | Chiles Center in Portland, OR | ESPN+ |
| Cal Poly Mustangs vs Fresno State Bulldogs | Friday, December 17, 2021 | 7:00 PM EST | Save Mart Center in Fresno, CA | ESPN+ |
| Cal Poly Mustangs vs UCLA Bruins | Thursday, December 23, 2021 | 10:00 PM EST | Pauley Pavilion presented by Wescom in Los Angeles, CA | PAC12 |
| Long Beach State 49ers vs Cal Poly Mustangs | Friday, December 31, 2021 | 10:00 PM EST | Robert A. Mott Athletics Center in San Luis Obispo, CA | ESPN+ |
| Cal Poly Mustangs vs UC Santa Barbara Gauchos | Friday, January 7, 2022 | 10:00 PM EST | The Thunderdome in Santa Barbara, CA | ESPN+ |
| Cal Poly Mustangs vs Cal State Northridge Matadors | Saturday, January 8, 2022 | 7:00 PM EST | Matadome in Northridge, CA | ESPN+ |
| UC Riverside Highlanders vs Cal Poly Mustangs | Thursday, January 13, 2022 | 7:00 PM EST | Robert A. Mott Athletics Center in San Luis Obispo, CA | ESPN+ |
| UC Davis Aggies vs Cal Poly Mustangs | Saturday, January 15, 2022 | 7:00 PM EST | Robert A. Mott Athletics Center in San Luis Obispo, CA | ESPN+ |
| Cal Poly Mustangs vs CSU Bakersfield Roadrunners | Tuesday, January 18, 2022 | 7:00 PM EST | Icardo Center in Bakersfield, CA | ESPN+ |
| Hawaii Warriors vs Cal Poly Mustangs | Saturday, January 22, 2022 | 7:00 PM EST | Robert A. Mott Athletics Center in San Luis Obispo, CA | ESPN+ |
| Cal Poly Mustangs vs San Diego Toreros | Friday, January 28, 2022 | 10:00 PM EST | RIMAC Arena in San Diego, CA | ESPN+ |
| Cal Poly Mustangs vs Cal State Fullerton Titans | Friday, February 4, 2022 | 10:00 PM EST | Titan Gym in Fullerton, CA | ESPN+ |
| Cal Poly Mustangs vs Long Beach State 49ers | Saturday, February 5, 2022 | 7:00 PM EST | Walter Pyramid in Long Beach, CA | ESPN+ |
| UC Santa Barbara Gauchos vs Cal Poly Mustangs | Saturday, February 12, 2022 | 7:00 PM EST | Robert A. Mott Athletics Center in San Luis Obispo, CA | ESPN+ |
| Cal Poly Mustangs vs UC Riverside Highlanders | Sunday, February 20, 2022 | 8:00 PM EST | SRC Arena in Riverside, CA | ESPN+ |
| CSU Bakersfield Roadrunners vs Cal Poly Mustangs | Tuesday, February 22, 2022 | 7:00 PM EST | Robert A. Mott Athletics Center in San Luis Obispo, CA | ESPN+ |
| Cal Poly Mustangs vs Hawaii Warriors | Thursday, February 24, 2022 | 7:00 PM EST | Stan Sheriff Center in Honolulu, HI | ESPN+ |
| UC Irvine Anteaters vs Cal Poly Mustangs | Thursday, March 3, 2022 | 7:00 PM EST | Robert A. Mott Athletics Center in San Luis Obispo, CA | ESPN+ |
