|
| Central Michigan Chippewas vs Missouri Tigers | Tuesday, November 9, 2021 | 6:00 PM EST | Mizzou Arena in Columbia, MO | ESPN+ |
| Central Michigan Chippewas vs DePaul Blue Demons | Saturday, November 13, 2021 | 6:00 PM EST | Wintrust Arena in Chicago, IL | FS2 |
| Central Michigan Chippewas vs Eastern Illinois Panthers | Monday, November 15, 2021 | 7:00 PM EST | Lantz Arena in Charleston, IL | ESPN+ |
| Gonzaga Bulldogs vs Central Michigan Chippewas | Tuesday, November 23, 2021 | 11:00 PM EST | T-Mobile Arena in Las Vegas, NV | ESPNU |
| Central Michigan Chippewas vs Bellarmine Knights | Wednesday, November 24, 2021 | 7:00 PM EST | T-Mobile Arena in Las Vegas, NV | ESPN+ |
| Central Michigan Chippewas vs Kentucky Wildcats | Monday, November 29, 2021 | 7:00 PM EST | Rupp Arena in Lexington, KY | ESPN+ |
| Central Michigan Chippewas vs Xavier Musketeers | Wednesday, December 1, 2021 | 6:30 PM EST | Cintas Center in Cincinnati, OH | FS1 |
| Western Illinois Leathernecks vs Central Michigan Chippewas | Sunday, December 5, 2021 | 7:00 PM EST | McGuirk Arena in Mount Pleasant, MI | ESPN+ |
| Central Michigan Chippewas vs Youngstown State Penguins | Wednesday, December 8, 2021 | 7:00 PM EST | Beeghly Center in Youngstown, OH | ESPN+ |
| UIC Flames vs Central Michigan Chippewas | Saturday, December 11, 2021 | 7:00 PM EST | McGuirk Arena in Mount Pleasant, MI | ESPN+ |
| Central Michigan Chippewas vs Detroit Titans | Saturday, December 18, 2021 | 7:00 PM EST | Calihan Hall in Detroit, MI | ESPN+ |
| Central Michigan Chippewas vs Kent State Golden Flashes | Tuesday, December 28, 2021 | 7:00 PM EST | M.A.C. Center in Kent, OH | ESPN+ |
| Toledo Rockets vs Central Michigan Chippewas | Tuesday, January 4, 2022 | 7:00 PM EST | McGuirk Arena in Mount Pleasant, MI | ESPN+ |
| Western Michigan Broncos vs Central Michigan Chippewas | Saturday, January 8, 2022 | 7:00 PM EST | McGuirk Arena in Mount Pleasant, MI | ESPN+ |
| Central Michigan Chippewas vs Eastern Michigan Eagles | Tuesday, January 11, 2022 | 7:00 PM EST | Convocation Center (MI) in Ypsilanti, MI | ESPN+ |
| Ohio Bobcats vs Central Michigan Chippewas | Saturday, January 15, 2022 | 7:00 PM EST | McGuirk Arena in Mount Pleasant, MI | ESPN+ |
| Central Michigan Chippewas vs Buffalo Bulls | Tuesday, January 18, 2022 | 7:00 PM EST | Alumni Arena in Buffalo, NY | ESPN+ |
| Ball State Cardinals vs Central Michigan Chippewas | Saturday, January 22, 2022 | 7:00 PM EST | McGuirk Arena in Mount Pleasant, MI | ESPN+ |
| Akron Zips vs Central Michigan Chippewas | Tuesday, January 25, 2022 | 7:00 PM EST | McGuirk Arena in Mount Pleasant, MI | ESPN+ |
| Bowling Green Falcons vs Central Michigan Chippewas | Tuesday, February 1, 2022 | 7:00 PM EST | McGuirk Arena in Mount Pleasant, MI | ESPN+ |
| Buffalo Bulls vs Central Michigan Chippewas | Saturday, February 5, 2022 | 7:00 PM EST | McGuirk Arena in Mount Pleasant, MI | ESPN+ |
| Central Michigan Chippewas vs Western Michigan Broncos | Saturday, February 12, 2022 | 7:00 PM EST | University Arena (MI) in Kalamazoo, MI | ESPN+ |
| Eastern Michigan Eagles vs Central Michigan Chippewas | Tuesday, February 15, 2022 | 7:00 PM EST | McGuirk Arena in Mount Pleasant, MI | ESPN+ |
| Central Michigan Chippewas vs Toledo Rockets | Saturday, February 19, 2022 | 7:00 PM EST | Savage Arena in Toledo, OH | ESPN+ |
| Central Michigan Chippewas vs Ohio Bobcats | Tuesday, February 22, 2022 | 7:00 PM EST | Convocation Center (OH) in Athens, OH | ESPN+ |
| Kent State Golden Flashes vs Central Michigan Chippewas | Saturday, February 26, 2022 | 7:00 PM EST | McGuirk Arena in Mount Pleasant, MI | ESPN+ |
| Miami RedHawks vs Central Michigan Chippewas | Tuesday, March 1, 2022 | 7:00 PM EST | McGuirk Arena in Mount Pleasant, MI | ESPN+ |
| Central Michigan Chippewas vs Akron Zips | Friday, March 4, 2022 | 7:00 PM EST | James A. Rhodes Arena in Akron, OH | ESPN+ |
