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| SIU Edwardsville Cougars vs Chicago State Cougars | Friday, November 12, 2021 | 6:30 PM EST | Jones Convocation Center in Chicago, IL | ESPN+ |
| Chicago State Cougars vs Loyola Ramblers | Tuesday, November 16, 2021 | 7:00 PM EST | Joseph J. Gentile Arena in Chicago, IL | ESPN+ |
| Chicago State Cougars vs Pacific Tigers | Tuesday, November 23, 2021 | 10:00 PM EST | Alex G. Spanos Center in Stockton, CA | ESPN+ |
| Chicago State Cougars vs Bowling Green Falcons | Sunday, November 28, 2021 | 7:00 PM EST | Stroh Center in Bowling Green, OH | ESPN+ |
| Illinois State Redbirds vs Chicago State Cougars | Saturday, December 11, 2021 | 7:00 PM EST | Jones Convocation Center in Chicago, IL | ESPN+ |
| Northern Illinois Huskies vs Chicago State Cougars | Monday, December 13, 2021 | 7:00 PM EST | Jones Convocation Center in Chicago, IL | ESPN+ |
| Chicago State Cougars vs Drake Bulldogs | Sunday, December 19, 2021 | 7:00 PM EST | The Knapp Center in Des Moines, IA | ESPN+ |
| Chicago State Cougars vs Iowa State Cyclones | Tuesday, December 21, 2021 | 7:00 PM EST | James H. Hilton Coliseum in Ames, IA | ESPN+ |
| Chicago State Cougars vs Grand Canyon Antelopes | Friday, December 31, 2021 | 8:00 PM EST | GCU Arena in Phoenix, AZ | ESPN+ |
| Seattle Redhawks vs Chicago State Cougars | Thursday, January 6, 2022 | 7:00 PM EST | Jones Convocation Center in Chicago, IL | ESPN+ |
| California Baptist Lancers vs Chicago State Cougars | Saturday, January 8, 2022 | 7:00 PM EST | Jones Convocation Center in Chicago, IL | ESPN+ |
| Chicago State Cougars vs UTRGV Vaqueros | Thursday, January 13, 2022 | 7:00 PM EST | UTRGV Fieldhouse in Edinburg, TX | ESPN+ |
| Chicago State Cougars vs Lamar Cardinals | Saturday, January 15, 2022 | 7:00 PM EST | Montagne Center in Beaumont, TX | ESPN+ |
| Utah Valley Wolverines vs Chicago State Cougars | Thursday, January 27, 2022 | 7:00 PM EST | Jones Convocation Center in Chicago, IL | ESPN+ |
| Sam Houston State Bearkats vs Chicago State Cougars | Saturday, February 12, 2022 | 7:00 PM EST | Jones Convocation Center in Chicago, IL | ESPN+ |
| Grand Canyon Antelopes vs Chicago State Cougars | Wednesday, February 23, 2022 | 7:00 PM EST | Jones Convocation Center in Chicago, IL | ESPN+ |
| New Mexico State Aggies vs Chicago State Cougars | Saturday, February 26, 2022 | 3:00 PM EST | Jones Convocation Center in Chicago, IL | ESPN+ |
| Chicago State Cougars vs California Baptist Lancers | Friday, March 4, 2022 | 10:00 PM EST | CBU Events Center in Riverside, CA | ESPN+ |
