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| Evansville Purple Aces vs Cincinnati Bearcats | Tuesday, November 9, 2021 | 7:00 PM EST | Fifth Third Arena in Cincinnati, OH | ESPN+ |
| Georgia Bulldogs vs Cincinnati Bearcats | Saturday, November 13, 2021 | 6:30 PM EST | Fifth Third Arena in Cincinnati, OH | ESPN+ |
| Alabama A&M Bulldogs vs Cincinnati Bearcats | Wednesday, November 17, 2021 | 8:00 PM EST | Fifth Third Arena in Cincinnati, OH | ESPN+ |
| Presbyterian Blue Hose vs Cincinnati Bearcats | Thursday, November 18, 2021 | 6:30 PM EST | Fifth Third Arena in Cincinnati, OH | ESPN+ |
| Cincinnati Bearcats vs Illinois Fighting Illini | Monday, November 22, 2021 | 6:30 PM EST | T-Mobile Center in Kansas City, MO | ESPN News |
| Monmouth Hawks vs Cincinnati Bearcats | Saturday, November 27, 2021 | 7:00 PM EST | Fifth Third Arena in Cincinnati, OH | ESPN+ |
| Cincinnati Bearcats vs Miami RedHawks | Wednesday, December 1, 2021 | 7:00 PM EST | Millett Hall in Oxford, OH | ESPN+ |
| Bryant Bulldogs vs Cincinnati Bearcats | Sunday, December 5, 2021 | 7:00 PM EST | Fifth Third Arena in Cincinnati, OH | ESPN+ |
| Cincinnati Bearcats vs Xavier Musketeers | Sunday, December 12, 2021 | 8:30 PM EST | Cintas Center in Cincinnati, OH | FS1 |
| Florida A&M Rattlers vs Cincinnati Bearcats | Tuesday, December 14, 2021 | 7:00 PM EST | Fifth Third Arena in Cincinnati, OH | ESPN+ |
| Texas Southern Tigers vs Cincinnati Bearcats | Saturday, December 18, 2021 | 7:00 PM EST | Fifth Third Arena in Cincinnati, OH | ESPN+ |
| Tennessee Tech Golden Eagles vs Cincinnati Bearcats | Tuesday, December 21, 2021 | 7:00 PM EST | Fifth Third Arena in Cincinnati, OH | ESPN+ |
| Cincinnati Bearcats vs Houston Cougars | Wednesday, December 29, 2021 | 8:00 PM EST | Fertitta Center in Houston, TX | ESPN2 |
| SMU Mustangs vs Cincinnati Bearcats | Friday, January 7, 2022 | 9:00 PM EST | Fifth Third Arena in Cincinnati, OH | ESPN+ |
| Cincinnati Bearcats vs Memphis Tigers | Sunday, January 9, 2022 | 3:30 PM EST | FedExForum in Memphis, TN | ABC |
| East Carolina Pirates vs Cincinnati Bearcats | Wednesday, January 12, 2022 | 7:00 PM EST | Fifth Third Arena in Cincinnati, OH | ESPN+ |
| Cincinnati Bearcats vs Wichita State Shockers | Sunday, January 16, 2022 | 1:00 PM EST | Charles Koch Arena in Wichita, KS | ESPN+ |
| Tulsa Golden Hurricane vs Cincinnati Bearcats | Friday, January 21, 2022 | 9:00 PM EST | Fifth Third Arena in Cincinnati, OH | ESPNU |
| Cincinnati Bearcats vs Temple Owls | Wednesday, January 26, 2022 | 7:00 PM EST | Liacouras Center in Philadelphia, PA | ESPNU |
| Cincinnati Bearcats vs East Carolina Pirates | Sunday, January 30, 2022 | 7:00 PM EST | Williams Arena at Minges Coliseum in Greenville, NC | ESPNU |
| Memphis Tigers vs Cincinnati Bearcats | Friday, February 4, 2022 | 7:00 PM EST | Fifth Third Arena in Cincinnati, OH | ESPN2 |
| Houston Cougars vs Cincinnati Bearcats | Sunday, February 6, 2022 | 6:00 PM EST | Fifth Third Arena in Cincinnati, OH | ESPN2 |
| Cincinnati Bearcats vs USF Bulls | Wednesday, February 9, 2022 | 7:00 PM EST | Yuengling Center in Tampa, FL | ESPN+ |
| Cincinnati Bearcats vs Tulsa Golden Hurricane | Saturday, February 12, 2022 | 7:00 PM EST | Donald W. Reynolds Center in Tulsa, OK | ESPN+ |
| Wichita State Shockers vs Cincinnati Bearcats | Thursday, February 17, 2022 | 7:00 PM EST | Fifth Third Arena in Cincinnati, OH | ESPN+ |
| Temple Owls vs Cincinnati Bearcats | Sunday, February 20, 2022 | 2:00 PM EST | Fifth Third Arena in Cincinnati, OH | ESPN+ |
| Cincinnati Bearcats vs UCF Knights | Thursday, February 24, 2022 | 9:00 PM EST | Addition Financial Arena in Orlando, FL | ESPNU |
| USF Bulls vs Cincinnati Bearcats | Saturday, February 26, 2022 | 7:00 PM EST | Fifth Third Arena in Cincinnati, OH | ESPN+ |
| Cincinnati Bearcats vs SMU Mustangs | Thursday, March 3, 2022 | 7:00 PM EST | Moody Coliseum in Dallas, TX | ESPN+ |
