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| Northeastern Huskies vs Colgate Raiders | Wednesday, November 10, 2021 | 7:00 PM EST | Cotterell Court in Hamilton, NY | ESPN+ |
| Colgate Raiders vs NC State Wolfpack | Saturday, November 13, 2021 | 2:00 PM EST | PNC Arena in Raleigh, NC | ESPN+ |
| Colgate Raiders vs Cornell Big Red | Wednesday, November 17, 2021 | 7:00 PM EST | Newman Arena in Ithaca, NY | ESPN+ |
| Colgate Raiders vs Harvard Crimson | Thursday, November 25, 2021 | 7:00 PM EST | Lavietes Pavilion in Cambridge, MA | ESPN+ |
| Niagara Purple Eagles vs Colgate Raiders | Tuesday, November 30, 2021 | 7:00 PM EST | Cotterell Court in Hamilton, NY | ESPN+ |
| Colgate Raiders vs Northeastern Huskies | Saturday, December 4, 2021 | 7:00 PM EST | Matthews Arena in Boston, MA | ESPN+ |
| Columbia Lions vs Colgate Raiders | Tuesday, December 7, 2021 | 7:00 PM EST | Cotterell Court in Hamilton, NY | ESPN+ |
| Colgate Raiders vs Pittsburgh Panthers | Friday, December 10, 2021 | 8:00 PM EST | Petersen Events Center in Pittsburgh, PA | ACC Network |
| Colgate Raiders vs St. John’s Red Storm | Sunday, December 12, 2021 | 12:00 PM EST | Carnesecca Arena in Queens, NY | FS1 |
| Colgate Raiders vs Monmouth Hawks | Sunday, December 19, 2021 | 2:00 PM EST | OceanFirst Bank Center in West Long Branch, NJ | ESPN+ |
| Colgate Raiders vs Vermont Catamounts | Wednesday, December 22, 2021 | 2:00 PM EST | Patrick Gymnasium in Burlington, VT | ESPN+ |
| Colgate Raiders vs Lehigh Mountain Hawks | Tuesday, January 4, 2022 | 7:00 PM EST | Stabler Arena in Bethlehem, PA | ESPN+ |
| Army Black Knights vs Colgate Raiders | Monday, January 10, 2022 | 7:00 PM EST | Cotterell Court in Hamilton, NY | ESPN+ |
| Colgate Raiders vs Navy Midshipmen | Friday, January 14, 2022 | 7:00 PM EST | Alumni Hall (Navy) in Annapolis, MD | ESPN+ |
| Holy Cross Crusaders vs Colgate Raiders | Sunday, January 16, 2022 | 7:00 PM EST | Cotterell Court in Hamilton, NY | ESPN+ |
| Colgate Raiders vs Bucknell Bison | Wednesday, January 19, 2022 | 7:00 PM EST | Sojka Pavilion in Lewisburg, PA | ESPN+ |
| Lafayette Leopards vs Colgate Raiders | Saturday, January 22, 2022 | 7:00 PM EST | Cotterell Court in Hamilton, NY | ESPN+ |
| Lehigh Mountain Hawks vs Colgate Raiders | Thursday, February 10, 2022 | 7:00 PM EST | Cotterell Court in Hamilton, NY | ESPN+ |
| Colgate Raiders vs Holy Cross Crusaders | Thursday, February 24, 2022 | 7:00 PM EST | Hart Center in Worcester, MA | ESPN+ |
| Navy Midshipmen vs Colgate Raiders | Saturday, February 26, 2022 | 2:00 PM EST | Cotterell Court in Hamilton, NY | ESPN+ |
