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| Central Connecticut Blue Devils vs Connecticut Huskies | Tuesday, November 9, 2021 | 6:30 PM EST | Gampel Pavilion in Storrs, CT | ESPN+ |
| LIU Brooklyn Blackbirds vs Connecticut Huskies | Wednesday, November 17, 2021 | 6:30 PM EST | Gampel Pavilion in Storrs, CT | FS2 |
| Connecticut Huskies vs Auburn Tigers | Wednesday, November 24, 2021 | 2:30 PM EST | Imperial Arena in Nassau, Bahamas | ESPN |
| Connecticut Huskies vs West Virginia Mountaineers | Thursday, December 9, 2021 | 7:00 PM EST | WVU Coliseum in Morgantown, WV | ESPN2 |
| Connecticut Huskies vs St. Bonaventure Bonnies | Saturday, December 11, 2021 | 4:00 PM EST | Prudential Center in Newark, NJ | ESPN2 |
| Providence Friars vs Connecticut Huskies | Saturday, December 18, 2021 | 5:00 PM EST | XL Center in Hartford, CT | FOX |
| Connecticut Huskies vs Marquette Golden Eagles | Wednesday, December 22, 2021 | 9:00 PM EST | Fiserv Forum in Milwaukee, WI | FS1 |
| Connecticut Huskies vs Xavier Musketeers | Wednesday, December 29, 2021 | 7:00 PM EST | Cintas Center in Cincinnati, OH | FS1 |
| Connecticut Huskies vs Seton Hall Pirates | Saturday, January 8, 2022 | 12:00 PM EST | Prudential Center in Newark, NJ | FOX |
| St. John’s Red Storm vs Connecticut Huskies | Thursday, January 13, 2022 | 8:30 PM EST | Gampel Pavilion in Storrs, CT | FS1 |
| Connecticut Huskies vs Providence Friars | Saturday, January 15, 2022 | 2:00 PM EST | Dunkin Donuts Center in Providence, RI | FS1 |
| Connecticut Huskies vs Butler Bulldogs | Friday, January 21, 2022 | 9:00 PM EST | Hinkle Fieldhouse in Indianapolis, IN | FS1 |
| Georgetown Hoyas vs Connecticut Huskies | Wednesday, January 26, 2022 | 8:30 PM EST | Gampel Pavilion in Storrs, CT | CBSSN |
| Creighton Bluejays vs Connecticut Huskies | Tuesday, February 1, 2022 | 6:30 PM EST | XL Center in Hartford, CT | FS1 |
| Connecticut Huskies vs Villanova Wildcats | Saturday, February 5, 2022 | 12:00 PM EST | Wells Fargo Center in Philadelphia, PA | FOX |
| Connecticut Huskies vs St. John’s Red Storm | Sunday, February 13, 2022 | 12:00 PM EST | Madison Square Garden in New York, NY | FOX |
| Xavier Musketeers vs Connecticut Huskies | Saturday, February 19, 2022 | 12:00 PM EST | Gampel Pavilion in Storrs, CT | FOX |
| Villanova Wildcats vs Connecticut Huskies | Wednesday, February 23, 2022 | 8:00 PM EST | XL Center in Hartford, CT | FS1 |
| Connecticut Huskies vs Creighton Bluejays | Thursday, March 3, 2022 | 8:30 PM EST | CHI Health Center Omaha in Omaha, NE | FS1 |
