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| Central Michigan Chippewas vs DePaul Blue Demons | Saturday, November 13, 2021 | 6:00 PM EST | Wintrust Arena in Chicago, IL | FS2 |
| Rutgers Scarlet Knights vs DePaul Blue Demons | Friday, November 19, 2021 | 8:30 PM EST | Wintrust Arena in Chicago, IL | FS1 |
| Northern Kentucky Norse vs DePaul Blue Demons | Friday, November 26, 2021 | 5:00 PM EST | Wintrust Arena in Chicago, IL | FS2 |
| Eastern Michigan Eagles vs DePaul Blue Demons | Sunday, November 28, 2021 | 2:00 PM EST | Wintrust Arena in Chicago, IL | FS1 |
| Duquesne Dukes vs DePaul Blue Demons | Wednesday, December 8, 2021 | 8:30 PM EST | Wintrust Arena in Chicago, IL | FS1 |
| DePaul Blue Demons vs Louisville Cardinals | Saturday, December 11, 2021 | 8:00 PM EST | KFC Yum! Center in Louisville, KY | ACC Network |
| DePaul Blue Demons vs UIC Flames | Wednesday, December 15, 2021 | 8:00 PM EST | Credit Union 1 Arena in Chicago, IL | ESPN+ |
| DePaul Blue Demons vs Northwestern Wildcats | Saturday, December 18, 2021 | 3:00 PM EST | Welsh-Ryan Arena in Evanston, IL | BTN |
| Creighton Bluejays vs DePaul Blue Demons | Monday, December 20, 2021 | 6:30 PM EST | Wintrust Arena in Chicago, IL | FS1 |
| Seton Hall Pirates vs DePaul Blue Demons | Friday, December 24, 2021 | 8:30 PM EST | Wintrust Arena in Chicago, IL | FS1 |
| DePaul Blue Demons vs Butler Bulldogs | Wednesday, December 29, 2021 | 5:00 PM EST | Hinkle Fieldhouse in Indianapolis, IN | FS1 |
| DePaul Blue Demons vs St. John’s Red Storm | Wednesday, January 5, 2022 | 6:30 PM EST | Carnesecca Arena in Queens, NY | FS1 |
| Villanova Wildcats vs DePaul Blue Demons | Saturday, January 8, 2022 | 7:00 PM EST | Wintrust Arena in Chicago, IL | FS1 |
| DePaul Blue Demons vs Marquette Golden Eagles | Wednesday, January 12, 2022 | 7:00 PM EST | Fiserv Forum in Milwaukee, WI | FS1 |
| Xavier Musketeers vs DePaul Blue Demons | Thursday, January 20, 2022 | 9:00 PM EST | Wintrust Arena in Chicago, IL | FS1 |
| DePaul Blue Demons vs Creighton Bluejays | Saturday, January 22, 2022 | 5:30 PM EST | CHI Health Center Omaha in Omaha, NE | CBSSN |
| DePaul Blue Demons vs Villanova Wildcats | Tuesday, January 25, 2022 | 5:00 PM EST | Finneran Pavilion in Villanova, PA | FS1 |
| DePaul Blue Demons vs Xavier Musketeers | Saturday, February 5, 2022 | 2:00 PM EST | Cintas Center in Cincinnati, OH | FS1 |
| Georgetown Hoyas vs DePaul Blue Demons | Thursday, February 10, 2022 | 9:00 PM EST | Wintrust Arena in Chicago, IL | FS1 |
| DePaul Blue Demons vs Providence Friars | Saturday, February 12, 2022 | 6:30 PM EST | Dunkin Donuts Center in Providence, RI | FS1 |
| Butler Bulldogs vs DePaul Blue Demons | Wednesday, February 16, 2022 | 9:00 PM EST | Wintrust Arena in Chicago, IL | FS1 |
| DePaul Blue Demons vs Seton Hall Pirates | Sunday, February 20, 2022 | 8:00 PM EST | Prudential Center in Newark, NJ | FS1 |
| DePaul Blue Demons vs Georgetown Hoyas | Friday, February 25, 2022 | 8:00 PM EST | Capital One Arena in Washington, DC | CBSSN |
| Marquette Golden Eagles vs DePaul Blue Demons | Thursday, March 3, 2022 | 9:00 PM EST | Wintrust Arena in Chicago, IL | CBSSN |
