|
| Detroit Titans vs Wyoming Cowboys | Wednesday, November 10, 2021 | 7:00 PM EST | Arena Auditorium in Laramie, WY | ESPN+ |
| Detroit Titans vs Toledo Rockets | Saturday, November 13, 2021 | 7:00 PM EST | Savage Arena in Toledo, OH | ESPN+ |
| Detroit Titans vs Mississippi State Bulldogs | Thursday, November 18, 2021 | 8:00 PM EST | Humphrey Coliseum in Starkville, MS | ESPN+ |
| Detroit Titans vs Hofstra Pride | Saturday, November 27, 2021 | 2:00 PM EST | David S. Mack Sports and Exhibition Complex in Hempstead, NY | ESPN+ |
| Detroit Titans vs Northeastern Huskies | Wednesday, December 1, 2021 | 7:00 PM EST | Matthews Arena in Boston, MA | ESPN+ |
| Detroit Titans vs IUPUI Jaguars | Thursday, December 2, 2021 | 7:00 PM EST | Indiana Farmers Coliseum in Indianapolis, IN | ESPN+ |
| Detroit Titans vs UIC Flames | Sunday, December 5, 2021 | 7:00 PM EST | Credit Union 1 Arena in Chicago, IL | ESPN+ |
| Detroit Titans vs Kent State Golden Flashes | Thursday, December 9, 2021 | 7:00 PM EST | M.A.C. Center in Kent, OH | ESPN+ |
| Western Michigan Broncos vs Detroit Titans | Saturday, December 11, 2021 | 7:00 PM EST | Calihan Hall in Detroit, MI | ESPN+ |
| Central Michigan Chippewas vs Detroit Titans | Saturday, December 18, 2021 | 7:00 PM EST | Calihan Hall in Detroit, MI | ESPN+ |
| Youngstown State Penguins vs Detroit Titans | Thursday, December 30, 2021 | 7:00 PM EST | Calihan Hall in Detroit, MI | ESPN+ |
| Oakland Golden Grizzlies vs Detroit Titans | Wednesday, January 5, 2022 | 7:00 PM EST | Calihan Hall in Detroit, MI | ESPN+ |
| Milwaukee Panthers vs Detroit Titans | Friday, January 7, 2022 | 7:00 PM EST | Calihan Hall in Detroit, MI | ESPN+ |
| Green Bay Phoenix vs Detroit Titans | Sunday, January 9, 2022 | 7:00 PM EST | Calihan Hall in Detroit, MI | ESPN+ |
| Detroit Titans vs Cleveland State Vikings | Saturday, January 15, 2022 | 7:00 PM EST | Wolstein Center in Cleveland, OH | ESPN+ |
| Detroit Titans vs Green Bay Phoenix | Thursday, January 20, 2022 | 7:00 PM EST | Resch Center in Ashwaubenon, WI | ESPN+ |
| Detroit Titans vs Milwaukee Panthers | Saturday, January 22, 2022 | 7:00 PM EST | UW-Milwaukee Panther Arena in Milwaukee, WI | ESPN+ |
| UIC Flames vs Detroit Titans | Thursday, January 27, 2022 | 7:00 PM EST | Calihan Hall in Detroit, MI | ESPN+ |
| Detroit Titans vs Wright State Raiders | Thursday, February 3, 2022 | 7:00 PM EST | Nutter Center in Dayton, OH | ESPN+ |
| Detroit Titans vs Northern Kentucky Norse | Saturday, February 5, 2022 | 7:00 PM EST | BB&T Arena in Highland Heights, KY | ESPN+ |
| Detroit Titans vs Robert Morris Colonials | Wednesday, February 9, 2022 | 7:00 PM EST | UPMC Events Center in Moon Township, PA | ESPN+ |
| Detroit Titans vs Youngstown State Penguins | Friday, February 11, 2022 | 7:00 PM EST | Beeghly Center in Youngstown, OH | ESPN+ |
| Detroit Titans vs Oakland Golden Grizzlies | Sunday, February 13, 2022 | 7:00 PM EST | Athletics Center O’rena in Rochester, MI | ESPN+ |
| Northern Kentucky Norse vs Detroit Titans | Friday, February 18, 2022 | 7:00 PM EST | Calihan Hall in Detroit, MI | ESPN+ |
| Wright State Raiders vs Detroit Titans | Sunday, February 20, 2022 | 7:00 PM EST | Calihan Hall in Detroit, MI | ESPN+ |
| Cleveland State Vikings vs Detroit Titans | Thursday, February 24, 2022 | 7:00 PM EST | Calihan Hall in Detroit, MI | ESPN+ |
