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| South Dakota Coyotes vs Drake Bulldogs | Sunday, November 14, 2021 | 3:00 PM EST | The Knapp Center in Des Moines, IA | ESPN+ |
| Belmont Bruins vs Drake Bulldogs | Friday, November 26, 2021 | 7:30 PM EST | HP Field House in Orlando, FL | ESPN+ |
| Valparaiso Crusaders vs Drake Bulldogs | Friday, December 3, 2021 | 9:00 PM EST | The Knapp Center in Des Moines, IA | ESPNU |
| Drake Bulldogs vs Omaha Mavericks | Thursday, December 9, 2021 | 8:00 PM EST | Baxter Arena in Omaha, NE | ESPN+ |
| Drake Bulldogs vs Clemson Tigers | Saturday, December 11, 2021 | 2:00 PM EST | State Farm Arena in Atlanta, GA | ACC Network |
| Chicago State Cougars vs Drake Bulldogs | Sunday, December 19, 2021 | 7:00 PM EST | The Knapp Center in Des Moines, IA | ESPN+ |
| Drake Bulldogs vs Saint Louis Billikens | Wednesday, December 22, 2021 | 7:00 PM EST | South Point Arena in Las Vegas, NV | ESPN+ |
| Drake Bulldogs vs Missouri State Bears | Sunday, January 2, 2022 | 7:00 PM EST | JQH Arena in Springfield, MO | ESPN+ |
| Drake Bulldogs vs Southern Illinois Salukis | Thursday, January 6, 2022 | 8:00 PM EST | Banterra Center in Carbondale, IL | ESPN+ |
| Indiana State Sycamores vs Drake Bulldogs | Saturday, January 8, 2022 | 7:00 PM EST | The Knapp Center in Des Moines, IA | ESPN+ |
| Illinois State Redbirds vs Drake Bulldogs | Wednesday, January 12, 2022 | 7:00 PM EST | The Knapp Center in Des Moines, IA | ESPN+ |
| Drake Bulldogs vs Evansville Purple Aces | Saturday, January 15, 2022 | 7:00 PM EST | Ford Center in Evansville, IN | ESPN+ |
| Bradley Braves vs Drake Bulldogs | Wednesday, January 19, 2022 | 7:00 PM EST | The Knapp Center in Des Moines, IA | ESPN+ |
| Drake Bulldogs vs UNI Panthers | Saturday, January 22, 2022 | 6:00 PM EST | McLeod Center in Cedar Falls, IA | ESPN+ |
| Drake Bulldogs vs Illinois State Redbirds | Wednesday, January 26, 2022 | 7:00 PM EST | Redbird Arena in Normal, IL | ESPN+ |
| Loyola Ramblers vs Drake Bulldogs | Sunday, January 30, 2022 | 7:00 PM EST | The Knapp Center in Des Moines, IA | ESPN+ |
| UNI Panthers vs Drake Bulldogs | Saturday, February 5, 2022 | 6:00 PM EST | The Knapp Center in Des Moines, IA | ESPN+ |
| Missouri State Bears vs Drake Bulldogs | Wednesday, February 9, 2022 | 7:00 PM EST | The Knapp Center in Des Moines, IA | ESPN+ |
| Drake Bulldogs vs Bradley Braves | Saturday, February 12, 2022 | 7:00 PM EST | Carver Arena in Peoria, IL | ESPN+ |
| Drake Bulldogs vs Loyola Ramblers | Saturday, February 19, 2022 | 6:00 PM EST | Joseph J. Gentile Arena in Chicago, IL | ESPN+ |
| Drake Bulldogs vs Valparaiso Crusaders | Wednesday, February 23, 2022 | 7:00 PM EST | Athletics-Recreation Center in Valparaiso, IN | ESPN+ |
| Southern Illinois Salukis vs Drake Bulldogs | Saturday, February 26, 2022 | 4:00 PM EST | The Knapp Center in Des Moines, IA | ESPN+ |
