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| USC Upstate Spartans vs East Tennessee State Buccaneers | Thursday, November 18, 2021 | 7:00 PM EST | Freedom Hall Civic Center in Johnson City, TN | ESPN+ |
| East Tennessee State Buccaneers vs Murray State Racers | Monday, November 22, 2021 | 5:30 PM EST | Moe Kent Family Field House in Naples, FL | ESPN+ |
| East Tennessee State Buccaneers vs UAB Blazers | Thursday, December 2, 2021 | 7:30 PM EST | Bartow Arena in Birmingham, AL | ESPN+ |
| Morehead State Eagles vs East Tennessee State Buccaneers | Saturday, December 11, 2021 | 7:00 PM EST | Freedom Hall Civic Center in Johnson City, TN | ESPN+ |
| North Carolina A&T Aggies vs East Tennessee State Buccaneers | Tuesday, December 14, 2021 | 7:00 PM EST | Freedom Hall Civic Center in Johnson City, TN | ESPN+ |
| East Tennessee State Buccaneers vs UNC Asheville Bulldogs | Saturday, December 18, 2021 | 7:00 PM EST | Kimmel Arena in Asheville, NC | ESPN+ |
| East Tennessee State Buccaneers vs Georgia Bulldogs | Wednesday, December 22, 2021 | 7:00 PM EST | Stegeman Coliseum in Athens, GA | ESPN+ |
| East Tennessee State Buccaneers vs Chattanooga Mocs | Friday, December 31, 2021 | 7:00 PM EST | McKenzie Arena in Chattanooga, TN | ESPNU |
| VMI Keydets vs East Tennessee State Buccaneers | Wednesday, January 5, 2022 | 7:00 PM EST | Freedom Hall Civic Center in Johnson City, TN | ESPN+ |
| Wofford Terriers vs East Tennessee State Buccaneers | Saturday, January 8, 2022 | 7:00 PM EST | Freedom Hall Civic Center in Johnson City, TN | ESPN+ |
| East Tennessee State Buccaneers vs Furman Paladins | Wednesday, January 12, 2022 | 7:00 PM EST | Timmons Arena in Greenville, SC | ESPN+ |
| East Tennessee State Buccaneers vs Samford Bulldogs | Saturday, January 15, 2022 | 7:00 PM EST | Pete Hanna Center in Birmingham, AL | ESPN+ |
| Mercer Bears vs East Tennessee State Buccaneers | Wednesday, January 19, 2022 | 7:00 PM EST | Freedom Hall Civic Center in Johnson City, TN | ESPN+ |
| Citadel Bulldogs vs East Tennessee State Buccaneers | Saturday, January 22, 2022 | 7:00 PM EST | Freedom Hall Civic Center in Johnson City, TN | ESPN+ |
| UNC Greensboro Spartans vs East Tennessee State Buccaneers | Wednesday, January 26, 2022 | 7:00 PM EST | Freedom Hall Civic Center in Johnson City, TN | ESPN+ |
| East Tennessee State Buccaneers vs Wofford Terriers | Saturday, February 5, 2022 | 7:00 PM EST | Jerry Richardson Indoor Stadium in Spartanburg, SC | ESPN+ |
| Furman Paladins vs East Tennessee State Buccaneers | Tuesday, February 8, 2022 | 7:00 PM EST | Freedom Hall Civic Center in Johnson City, TN | ESPNU |
| Samford Bulldogs vs East Tennessee State Buccaneers | Saturday, February 12, 2022 | 7:00 PM EST | Freedom Hall Civic Center in Johnson City, TN | ESPN+ |
| East Tennessee State Buccaneers vs Citadel Bulldogs | Saturday, February 19, 2022 | 7:00 PM EST | McAlister Field House in Charleston, SC | ESPN+ |
| Chattanooga Mocs vs East Tennessee State Buccaneers | Wednesday, February 23, 2022 | 7:00 PM EST | Freedom Hall Civic Center in Johnson City, TN | ESPN+ |
