|
| Florida Gulf Coast Eagles vs Loyola Ramblers | Saturday, November 13, 2021 | 7:00 PM EST | Joseph J. Gentile Arena in Chicago, IL | ESPN+ |
| USC Trojans vs Florida Gulf Coast Eagles | Tuesday, November 16, 2021 | 6:00 PM EST | Alico Arena in Fort Myers, FL | ESPNU |
| Rhode Island Rams vs Florida Gulf Coast Eagles | Wednesday, November 24, 2021 | 7:00 PM EST | Alico Arena in Fort Myers, FL | ESPN+ |
| Western Michigan Broncos vs Florida Gulf Coast Eagles | Friday, November 26, 2021 | 7:00 PM EST | Alico Arena in Fort Myers, FL | ESPN+ |
| SE Louisiana Lions vs Florida Gulf Coast Eagles | Sunday, November 28, 2021 | 7:00 PM EST | Alico Arena in Fort Myers, FL | ESPN+ |
| Florida Gulf Coast Eagles vs FIU Panthers | Wednesday, December 1, 2021 | 7:00 PM EST | Ocean Bank Convocation Center in Miami, FL | ESPN+ |
| Florida Gulf Coast Eagles vs Florida A&M Rattlers | Tuesday, December 7, 2021 | 7:00 PM EST | Al Lawson Center in Tallahassee, FL | ESPN+ |
| Florida Gulf Coast Eagles vs Robert Morris Colonials | Saturday, December 11, 2021 | 7:00 PM EST | UPMC Events Center in Moon Township, PA | ESPN+ |
| Mercer Bears vs Florida Gulf Coast Eagles | Sunday, December 19, 2021 | 7:00 PM EST | Alico Arena in Fort Myers, FL | ESPN+ |
| North Florida Ospreys vs Florida Gulf Coast Eagles | Tuesday, January 4, 2022 | 7:00 PM EST | Alico Arena in Fort Myers, FL | ESPN+ |
| Florida Gulf Coast Eagles vs Jacksonville Dolphins | Saturday, January 8, 2022 | 7:00 PM EST | Swisher Gymnasium in Jacksonville, FL | ESPN+ |
| Florida Gulf Coast Eagles vs Kennesaw State Owls | Tuesday, January 11, 2022 | 7:00 PM EST | KSU Convocation Center in Kennesaw, GA | ESPN+ |
| Liberty Flames vs Florida Gulf Coast Eagles | Saturday, January 15, 2022 | 7:00 PM EST | Alico Arena in Fort Myers, FL | ESPN+ |
| Florida Gulf Coast Eagles vs Stetson Hatters | Tuesday, January 18, 2022 | 7:00 PM EST | Edmunds Center in Deland, FL | ESPN+ |
| Florida Gulf Coast Eagles vs Jacksonville State Gamecocks | Saturday, January 22, 2022 | 7:00 PM EST | Pete Mathews Coliseum in Jacksonville, AL | ESPN+ |
| Eastern Kentucky Colonels vs Florida Gulf Coast Eagles | Thursday, January 27, 2022 | 7:00 PM EST | Alico Arena in Fort Myers, FL | ESPN+ |
| Florida Gulf Coast Eagles vs Central Arkansas Bears | Thursday, February 3, 2022 | 7:00 PM EST | Farris Center in Conway, AR | ESPN+ |
| Florida Gulf Coast Eagles vs Lipscomb Bisons | Saturday, February 5, 2022 | 7:00 PM EST | Allen Arena in Nashville, TN | ESPN+ |
| North Alabama Lions vs Florida Gulf Coast Eagles | Wednesday, February 9, 2022 | 7:00 PM EST | Alico Arena in Fort Myers, FL | ESPN+ |
| Stetson Hatters vs Florida Gulf Coast Eagles | Saturday, February 12, 2022 | 7:00 PM EST | Alico Arena in Fort Myers, FL | ESPN+ |
| Florida Gulf Coast Eagles vs North Florida Ospreys | Saturday, February 19, 2022 | 7:00 PM EST | UNF Arena in Jacksonville, FL | ESPN+ |
| Florida Gulf Coast Eagles vs Liberty Flames | Wednesday, February 23, 2022 | 7:00 PM EST | Liberty Arena in Lynchburg, VA | ESPN+ |
| Jacksonville Dolphins vs Florida Gulf Coast Eagles | Saturday, February 26, 2022 | 7:00 PM EST | Alico Arena in Fort Myers, FL | ESPN+ |
