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| Stony Brook Seawolves vs George Mason Patriots | Tuesday, November 9, 2021 | 4:30 PM EST | EagleBank Arena in Fairfax, VA | ESPN+ |
| Penn Quakers vs George Mason Patriots | Saturday, November 13, 2021 | 7:00 PM EST | EagleBank Arena in Fairfax, VA | ESPN+ |
| Morgan State Bears vs George Mason Patriots | Sunday, November 14, 2021 | 6:00 PM EST | EagleBank Arena in Fairfax, VA | ESPN+ |
| George Mason Patriots vs Maryland Terrapins | Thursday, November 18, 2021 | 7:00 PM EST | XFINITY Center in College Park, MD | BTN |
| George Mason Patriots vs James Madison Dukes | Saturday, November 20, 2021 | 7:00 PM EST | Atlantic Union Bank Center in Harrisonburg, VA | ESPN+ |
| George Mason Patriots vs South Dakota State Jackrabbits | Thursday, November 25, 2021 | 9:30 PM EST | Sanford Pentagon in Sioux Falls, SD | ESPN+ |
| Navy Midshipmen vs George Mason Patriots | Wednesday, December 8, 2021 | 7:00 PM EST | EagleBank Arena in Fairfax, VA | ESPN+ |
| George Mason Patriots vs Georgia Bulldogs | Saturday, December 18, 2021 | 7:00 PM EST | Stegeman Coliseum in Athens, GA | ESPN+ |
| George Mason Patriots vs VCU Rams | Thursday, December 30, 2021 | 7:00 PM EST | Stuart C. Siegel Center in Richmond, VA | ESPN+ |
| George Mason Patriots vs Duquesne Dukes | Sunday, January 2, 2022 | 2:00 PM EST | UPMC Cooper Fieldhouse in Pittsburgh, PA | ESPN+ |
| Rhode Island Rams vs George Mason Patriots | Wednesday, January 5, 2022 | 7:00 PM EST | EagleBank Arena in Fairfax, VA | ESPN+ |
| Saint Joseph’s Hawks vs George Mason Patriots | Saturday, January 8, 2022 | 7:00 PM EST | EagleBank Arena in Fairfax, VA | ESPN+ |
| George Mason Patriots vs Richmond Spiders | Wednesday, January 12, 2022 | 7:00 PM EST | Robins Center in Richmond, VA | ESPN+ |
| George Mason Patriots vs George Washington Colonials | Monday, January 17, 2022 | 7:00 PM EST | Charles E. Smith Center in Washington, DC | ESPN+ |
| Dayton Flyers vs George Mason Patriots | Saturday, January 22, 2022 | 7:00 PM EST | EagleBank Arena in Fairfax, VA | ESPN+ |
| St. Bonaventure Bonnies vs George Mason Patriots | Wednesday, January 26, 2022 | 7:00 PM EST | EagleBank Arena in Fairfax, VA | ESPN+ |
| George Mason Patriots vs UMass Minutemen | Sunday, January 30, 2022 | 2:00 PM EST | William D. Mullins Memorial Center in Amherst, MA | ESPN+ |
| George Mason Patriots vs La Salle Explorers | Saturday, February 5, 2022 | 7:00 PM EST | Tom Gola Arena in Philadelphia, PA | ESPN+ |
| Richmond Spiders vs George Mason Patriots | Wednesday, February 9, 2022 | 7:00 PM EST | EagleBank Arena in Fairfax, VA | ESPN+ |
| VCU Rams vs George Mason Patriots | Saturday, February 12, 2022 | 7:00 PM EST | EagleBank Arena in Fairfax, VA | ESPN+ |
| George Mason Patriots vs Fordham Rams | Sunday, February 20, 2022 | 2:30 PM EST | Rose Hill Gymnasium in Bronx, NY | ESPN+ |
| George Mason Patriots vs Davidson Wildcats | Wednesday, March 2, 2022 | 7:00 PM EST | John M. Belk Arena in Davidson, NC | ESPN+ |
