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| Dartmouth Big Green vs Georgetown Hoyas | Saturday, November 13, 2021 | 7:00 PM EST | Capital One Arena in Washington, DC | FS1 |
| Georgetown Hoyas vs San Diego State Aztecs | Friday, November 26, 2021 | 11:59 PM EST | Anaheim Convention Center in Anaheim, CA | ESPN2 |
| Longwood Lancers vs Georgetown Hoyas | Tuesday, November 30, 2021 | 7:00 PM EST | Capital One Arena in Washington, DC | ESPN+ |
| Georgetown Hoyas vs South Carolina Gamecocks | Sunday, December 5, 2021 | 2:00 PM EST | Colonial Life Arena in Columbia, SC | SEC Network |
| UMBC Retrievers vs Georgetown Hoyas | Wednesday, December 8, 2021 | 7:00 PM EST | Capital One Arena in Washington, DC | ESPN+ |
| Syracuse Orange vs Georgetown Hoyas | Saturday, December 11, 2021 | 7:00 PM EST | Capital One Arena in Washington, DC | ESPN+ |
| Howard Bison vs Georgetown Hoyas | Wednesday, December 15, 2021 | 6:30 PM EST | Capital One Arena in Washington, DC | ESPN+ |
| TCU Horned Frogs vs Georgetown Hoyas | Saturday, December 18, 2021 | 2:00 PM EST | Capital One Arena in Washington, DC | ESPN+ |
| Georgetown Hoyas vs Providence Friars | Wednesday, December 22, 2021 | 6:30 PM EST | Dunkin Donuts Center in Providence, RI | FS1 |
| Georgetown Hoyas vs Creighton Bluejays | Wednesday, December 29, 2021 | 9:00 PM EST | CHI Health Center Omaha in Omaha, NE | FS1 |
| Xavier Musketeers vs Georgetown Hoyas | Wednesday, January 5, 2022 | 7:00 PM EST | Capital One Arena in Washington, DC | FS1 |
| Marquette Golden Eagles vs Georgetown Hoyas | Friday, January 7, 2022 | 6:30 PM EST | Capital One Arena in Washington, DC | FS1 |
| Butler Bulldogs vs Georgetown Hoyas | Friday, January 14, 2022 | 7:00 PM EST | Capital One Arena in Washington, DC | FS1 |
| Georgetown Hoyas vs St. John’s Red Storm | Sunday, January 16, 2022 | 7:00 PM EST | Madison Square Garden in New York, NY | FOX |
| Villanova Wildcats vs Georgetown Hoyas | Saturday, January 22, 2022 | 12:00 PM EST | Capital One Arena in Washington, DC | FOX |
| Georgetown Hoyas vs Connecticut Huskies | Wednesday, January 26, 2022 | 8:30 PM EST | Gampel Pavilion in Storrs, CT | CBSSN |
| Seton Hall Pirates vs Georgetown Hoyas | Wednesday, February 2, 2022 | 8:30 PM EST | Capital One Arena in Washington, DC | FS1 |
| Providence Friars vs Georgetown Hoyas | Sunday, February 6, 2022 | 12:00 PM EST | Capital One Arena in Washington, DC | FS1 |
| Georgetown Hoyas vs DePaul Blue Demons | Thursday, February 10, 2022 | 9:00 PM EST | Wintrust Arena in Chicago, IL | FS1 |
| Creighton Bluejays vs Georgetown Hoyas | Saturday, February 12, 2022 | 12:00 PM EST | Capital One Arena in Washington, DC | FS1 |
| Georgetown Hoyas vs Villanova Wildcats | Saturday, February 19, 2022 | 5:00 PM EST | Finneran Pavilion in Villanova, PA | FOX |
| DePaul Blue Demons vs Georgetown Hoyas | Friday, February 25, 2022 | 8:00 PM EST | Capital One Arena in Washington, DC | CBSSN |
| Georgetown Hoyas vs Seton Hall Pirates | Thursday, March 3, 2022 | 7:00 PM EST | Prudential Center in Newark, NJ | CBSSN |
