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| High Point Panthers vs Northwestern Wildcats | Friday, November 12, 2021 | 6:30 PM EST | Welsh-Ryan Arena in Evanston, IL | ESPN+ |
| High Point Panthers vs Notre Dame Fighting Irish | Wednesday, November 17, 2021 | 8:00 PM EST | Purcell Pavilion in South Bend, IN | ACC Network |
| Furman Paladins vs High Point Panthers | Wednesday, December 1, 2021 | 7:00 PM EST | Nido and Mariana Qubein Arena in High Point, NC | ESPN+ |
| High Point Panthers vs South Carolina State Bulldogs | Friday, December 10, 2021 | 7:00 PM EST | Rock Hill Sports & Event Center in Rock Hill, SC | ESPN+ |
| UNC Wilmington Seahawks vs High Point Panthers | Saturday, December 18, 2021 | 2:00 PM EST | Nido and Mariana Qubein Arena in High Point, NC | ESPN+ |
| Florida Atlantic Owls vs High Point Panthers | Wednesday, December 22, 2021 | 7:00 PM EST | Nido and Mariana Qubein Arena in High Point, NC | ESPN+ |
| High Point Panthers vs Michigan State Spartans | Wednesday, December 29, 2021 | 7:00 PM EST | Breslin Center in East Lansing, MI | BTN |
| Winthrop Eagles vs High Point Panthers | Wednesday, January 5, 2022 | 7:00 PM EST | Nido and Mariana Qubein Arena in High Point, NC | ESPN+ |
| High Point Panthers vs Longwood Lancers | Saturday, January 8, 2022 | 7:00 PM EST | Willett Hall in Farmville, VA | ESPN+ |
| High Point Panthers vs USC Upstate Spartans | Wednesday, January 12, 2022 | 7:00 PM EST | G.B. Hodge Center in Spartanburg, SC | ESPN+ |
| North Carolina A&T Aggies vs High Point Panthers | Saturday, January 15, 2022 | 7:00 PM EST | Nido and Mariana Qubein Arena in High Point, NC | ESPN+ |
| High Point Panthers vs Charleston Southern Buccaneers | Wednesday, January 19, 2022 | 7:00 PM EST | Buccaneer Fieldhouse in Charleston, SC | ESPN+ |
| High Point Panthers vs Hampton Pirates | Saturday, January 22, 2022 | 7:00 PM EST | Convocation Center (VA) in Hampton, VA | ESPN+ |
| Radford Highlanders vs High Point Panthers | Wednesday, January 26, 2022 | 7:00 PM EST | Nido and Mariana Qubein Arena in High Point, NC | ESPN+ |
| UNC Asheville Bulldogs vs High Point Panthers | Saturday, February 5, 2022 | 7:00 PM EST | Nido and Mariana Qubein Arena in High Point, NC | ESPN+ |
| High Point Panthers vs Presbyterian Blue Hose | Wednesday, February 9, 2022 | 7:00 PM EST | Ross E. Templeton P.E. Center in Clinton, SC | ESPN+ |
| Campbell Fighting Camels vs High Point Panthers | Saturday, February 12, 2022 | 7:00 PM EST | Nido and Mariana Qubein Arena in High Point, NC | ESPN+ |
| High Point Panthers vs Radford Highlanders | Saturday, February 19, 2022 | 7:00 PM EST | Donald N. Dedmon Center in Radford, VA | ESPN+ |
| High Point Panthers vs North Carolina A&T Aggies | Wednesday, February 23, 2022 | 7:00 PM EST | Corbett Sports Center in Greensboro, NC | ESPN+ |
| Hampton Pirates vs High Point Panthers | Saturday, February 26, 2022 | 7:00 PM EST | Nido and Mariana Qubein Arena in High Point, NC | ESPN+ |
