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| Holy Cross Crusaders vs Boston College Eagles | Saturday, November 13, 2021 | 7:00 PM EST | Silvio O. Conte Forum in Chestnut Hill, MA | ESPN+ |
| Holy Cross Crusaders vs Quinnipiac Bobcats | Tuesday, November 16, 2021 | 7:00 PM EST | People’s United Center in Hamden, CT | ESPN+ |
| New Hampshire Wildcats vs Holy Cross Crusaders | Saturday, November 27, 2021 | 2:00 PM EST | Hart Center in Worcester, MA | ESPN+ |
| Holy Cross Crusaders vs Central Connecticut Blue Devils | Wednesday, December 1, 2021 | 7:00 PM EST | William H. Detrick Gymnasium in New Britain, CT | ESPN+ |
| Holy Cross Crusaders vs Fairfield Stags | Thursday, December 9, 2021 | 7:00 PM EST | Webster Bank Arena in Bridgeport, CT | ESPN+ |
| Siena Saints vs Holy Cross Crusaders | Saturday, December 11, 2021 | 2:00 PM EST | Hart Center in Worcester, MA | ESPN+ |
| Holy Cross Crusaders vs Harvard Crimson | Sunday, December 19, 2021 | 2:00 PM EST | Lavietes Pavilion in Cambridge, MA | ESPN+ |
| Holy Cross Crusaders vs Saint Joseph’s Hawks | Wednesday, December 22, 2021 | 7:00 PM EST | Michael J. Hagan ’85 Arena in Philadelphia, PA | ESPN+ |
| Lafayette Leopards vs Holy Cross Crusaders | Saturday, January 8, 2022 | 7:00 PM EST | Hart Center in Worcester, MA | ESPN+ |
| Holy Cross Crusaders vs Lehigh Mountain Hawks | Monday, January 10, 2022 | 7:00 PM EST | Stabler Arena in Bethlehem, PA | ESPN+ |
| Holy Cross Crusaders vs Colgate Raiders | Sunday, January 16, 2022 | 7:00 PM EST | Cotterell Court in Hamilton, NY | ESPN+ |
| Holy Cross Crusaders vs Lafayette Leopards | Wednesday, January 19, 2022 | 7:00 PM EST | Kirby Sports Center in Easton, PA | ESPN+ |
| Bucknell Bison vs Holy Cross Crusaders | Saturday, January 22, 2022 | 2:00 PM EST | Hart Center in Worcester, MA | ESPN+ |
| Holy Cross Crusaders vs Army Black Knights | Saturday, February 5, 2022 | 7:00 PM EST | Christl Arena in West Point, NY | ESPN+ |
| Holy Cross Crusaders vs Bucknell Bison | Saturday, February 12, 2022 | 7:00 PM EST | Sojka Pavilion in Lewisburg, PA | ESPN+ |
| Holy Cross Crusaders vs Navy Midshipmen | Saturday, February 19, 2022 | 12:00 PM EST | Alumni Hall (Navy) in Annapolis, MD | ESPN+ |
| Colgate Raiders vs Holy Cross Crusaders | Thursday, February 24, 2022 | 7:00 PM EST | Hart Center in Worcester, MA | ESPN+ |
| Army Black Knights vs Holy Cross Crusaders | Saturday, February 26, 2022 | 2:00 PM EST | Hart Center in Worcester, MA | ESPN+ |
