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| Jackson State Tigers vs Illinois Fighting Illini | Wednesday, November 10, 2021 | 8:30 PM EST | State Farm Center in Champaign, IL | BTN |
| Arkansas State Red Wolves vs Illinois Fighting Illini | Friday, November 12, 2021 | 7:00 PM EST | State Farm Center in Champaign, IL | ESPN+ |
| Illinois Fighting Illini vs Marquette Golden Eagles | Tuesday, November 16, 2021 | 7:00 PM EST | Fiserv Forum in Milwaukee, WI | FS1 |
| Cincinnati Bearcats vs Illinois Fighting Illini | Monday, November 22, 2021 | 6:30 PM EST | T-Mobile Center in Kansas City, MO | ESPN News |
| UTRGV Vaqueros vs Illinois Fighting Illini | Friday, November 26, 2021 | 7:00 PM EST | State Farm Center in Champaign, IL | ESPN+ |
| Notre Dame Fighting Irish vs Illinois Fighting Illini | Tuesday, November 30, 2021 | 9:00 PM EST | State Farm Center in Champaign, IL | ESPN2 |
| Rutgers Scarlet Knights vs Illinois Fighting Illini | Saturday, December 4, 2021 | 7:00 PM EST | State Farm Center in Champaign, IL | ESPN2 |
| Illinois Fighting Illini vs Iowa Hawkeyes | Tuesday, December 7, 2021 | 7:00 PM EST | Carver-Hawkeye Arena in Iowa City, IA | FS1 |
| Arizona Wildcats vs Illinois Fighting Illini | Saturday, December 11, 2021 | 5:00 PM EST | State Farm Center in Champaign, IL | FOX |
| Saint Francis Red Flash vs Illinois Fighting Illini | Saturday, December 18, 2021 | 1:00 PM EST | State Farm Center in Champaign, IL | BTN |
| Florida A&M Rattlers vs Illinois Fighting Illini | Wednesday, December 29, 2021 | 7:00 PM EST | State Farm Center in Champaign, IL | BTN |
| Illinois Fighting Illini vs Minnesota Golden Gophers | Sunday, January 2, 2022 | 6:00 PM EST | Williams Arena in Minneapolis, MN | BTN |
| Maryland Terrapins vs Illinois Fighting Illini | Friday, January 7, 2022 | 7:00 PM EST | State Farm Center in Champaign, IL | ESPN2 |
| Illinois Fighting Illini vs Nebraska Cornhuskers | Wednesday, January 12, 2022 | 8:30 PM EST | Pinnacle Bank Arena in Lincoln, NE | BTN |
| Purdue Boilermakers vs Illinois Fighting Illini | Monday, January 17, 2022 | 12:00 PM EST | State Farm Center in Champaign, IL | FOX |
| Illinois Fighting Illini vs Maryland Terrapins | Saturday, January 22, 2022 | 7:00 PM EST | XFINITY Center in College Park, MD | FS1 |
| Michigan State Spartans vs Illinois Fighting Illini | Wednesday, January 26, 2022 | 7:00 PM EST | State Farm Center in Champaign, IL | ESPN+ |
| Illinois Fighting Illini vs Indiana Hoosiers | Saturday, February 5, 2022 | 12:00 PM EST | Simon Skjodt Assembly Hall in Bloomington, IN | ESPN+ |
| Northwestern Wildcats vs Illinois Fighting Illini | Sunday, February 13, 2022 | 2:00 PM EST | State Farm Center in Champaign, IL | BTN |
| Illinois Fighting Illini vs Michigan State Spartans | Saturday, February 19, 2022 | 2:30 PM EST | Breslin Center in East Lansing, MI | FOX |
| Ohio State Buckeyes vs Illinois Fighting Illini | Friday, February 25, 2022 | 9:00 PM EST | State Farm Center in Champaign, IL | FS1 |
| Penn State Nittany Lions vs Illinois Fighting Illini | Friday, March 4, 2022 | 7:00 PM EST | State Farm Center in Champaign, IL | FOX |
