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| Indiana State Sycamores vs Green Bay Phoenix | Tuesday, November 9, 2021 | 7:00 PM EST | Resch Center in Ashwaubenon, WI | ESPN+ |
| Indiana State Sycamores vs Purdue Boilermakers | Friday, November 12, 2021 | 7:00 PM EST | Mackey Arena in West Lafayette, IN | BTN |
| Indiana State Sycamores vs Old Dominion Monarchs | Friday, November 19, 2021 | 9:30 PM EST | The HTC Center in Conway, SC | ESPNU |
| Indiana State Sycamores vs Ball State Cardinals | Saturday, November 27, 2021 | 7:00 PM EST | Worthen Arena in Muncie, IN | ESPN+ |
| Indiana State Sycamores vs Loyola Ramblers | Wednesday, December 1, 2021 | 7:00 PM EST | Joseph J. Gentile Arena in Chicago, IL | ESPN+ |
| Indiana State Sycamores vs North Dakota State Bison | Monday, December 13, 2021 | 7:00 PM EST | Scheels Center in Fargo, ND | ESPN+ |
| Alabama A&M Bulldogs vs Indiana State Sycamores | Saturday, December 18, 2021 | 1:00 PM EST | Hulman Center in Terre Haute, IN | ESPN+ |
| Indiana State Sycamores vs Northern Illinois Huskies | Wednesday, December 22, 2021 | 7:00 PM EST | NIU Convocation Center in Dekalb, IL | ESPN+ |
| Bradley Braves vs Indiana State Sycamores | Sunday, January 2, 2022 | 7:00 PM EST | Hulman Center in Terre Haute, IN | ESPN+ |
| Evansville Purple Aces vs Indiana State Sycamores | Wednesday, January 5, 2022 | 7:00 PM EST | Hulman Center in Terre Haute, IN | ESPN+ |
| Indiana State Sycamores vs Drake Bulldogs | Saturday, January 8, 2022 | 7:00 PM EST | The Knapp Center in Des Moines, IA | ESPN+ |
| Indiana State Sycamores vs UNI Panthers | Tuesday, January 11, 2022 | 7:00 PM EST | McLeod Center in Cedar Falls, IA | ESPN+ |
| Loyola Ramblers vs Indiana State Sycamores | Saturday, January 15, 2022 | 7:00 PM EST | Hulman Center in Terre Haute, IN | ESPN+ |
| Indiana State Sycamores vs Southern Illinois Salukis | Wednesday, January 19, 2022 | 7:00 PM EST | Banterra Center in Carbondale, IL | ESPN+ |
| Valparaiso Crusaders vs Indiana State Sycamores | Saturday, January 22, 2022 | 7:00 PM EST | Hulman Center in Terre Haute, IN | ESPN+ |
| Missouri State Bears vs Indiana State Sycamores | Tuesday, January 25, 2022 | 7:00 PM EST | Hulman Center in Terre Haute, IN | ESPN+ |
| Indiana State Sycamores vs Bradley Braves | Sunday, January 30, 2022 | 7:00 PM EST | Carver Arena in Peoria, IL | ESPN+ |
| Indiana State Sycamores vs Valparaiso Crusaders | Saturday, February 5, 2022 | 7:00 PM EST | Athletics-Recreation Center in Valparaiso, IN | ESPN+ |
| Indiana State Sycamores vs Evansville Purple Aces | Wednesday, February 9, 2022 | 7:00 PM EST | Ford Center in Evansville, IN | ESPN+ |
| Illinois State Redbirds vs Indiana State Sycamores | Saturday, February 12, 2022 | 7:00 PM EST | Hulman Center in Terre Haute, IN | ESPN+ |
| Indiana State Sycamores vs Missouri State Bears | Tuesday, February 15, 2022 | 7:00 PM EST | JQH Arena in Springfield, MO | ESPN+ |
| Southern Illinois Salukis vs Indiana State Sycamores | Saturday, February 19, 2022 | 7:00 PM EST | Hulman Center in Terre Haute, IN | ESPN+ |
| UNI Panthers vs Indiana State Sycamores | Wednesday, February 23, 2022 | 7:00 PM EST | Hulman Center in Terre Haute, IN | ESPN+ |
| Indiana State Sycamores vs Illinois State Redbirds | Saturday, February 26, 2022 | 7:00 PM EST | Redbird Arena in Normal, IL | ESPN+ |
