|
| Longwood Lancers vs Iowa Hawkeyes | Tuesday, November 9, 2021 | 4:00 PM EST | Carver-Hawkeye Arena in Iowa City, IA | ESPN+ |
| North Carolina Central Eagles vs Iowa Hawkeyes | Wednesday, November 17, 2021 | 9:00 PM EST | Carver-Hawkeye Arena in Iowa City, IA | BTN |
| Alabama State Hornets vs Iowa Hawkeyes | Friday, November 19, 2021 | 7:00 PM EST | Carver-Hawkeye Arena in Iowa City, IA | BTN |
| Western Michigan Broncos vs Iowa Hawkeyes | Tuesday, November 23, 2021 | 8:30 PM EST | Carver-Hawkeye Arena in Iowa City, IA | BTN |
| Portland State Vikings vs Iowa Hawkeyes | Friday, November 26, 2021 | 7:00 PM EST | Carver-Hawkeye Arena in Iowa City, IA | ESPN+ |
| Iowa Hawkeyes vs Virginia Cavaliers | Tuesday, November 30, 2021 | 7:00 PM EST | John Paul Jones Arena in Charlottesville, VA | ESPN2 |
| Iowa Hawkeyes vs Purdue Boilermakers | Saturday, December 4, 2021 | 9:00 PM EST | Mackey Arena in West Lafayette, IN | BTN |
| Illinois Fighting Illini vs Iowa Hawkeyes | Tuesday, December 7, 2021 | 7:00 PM EST | Carver-Hawkeye Arena in Iowa City, IA | FS1 |
| Iowa Hawkeyes vs Iowa State Cyclones | Friday, December 10, 2021 | 9:00 PM EST | James H. Hilton Coliseum in Ames, IA | ESPN2 |
| SE Louisiana Lions vs Iowa Hawkeyes | Tuesday, December 21, 2021 | 7:00 PM EST | Carver-Hawkeye Arena in Iowa City, IA | ESPN+ |
| Western Illinois Leathernecks vs Iowa Hawkeyes | Wednesday, December 29, 2021 | 7:00 PM EST | Carver-Hawkeye Arena in Iowa City, IA | ESPN+ |
| Maryland Terrapins vs Iowa Hawkeyes | Tuesday, January 4, 2022 | 9:00 PM EST | Carver-Hawkeye Arena in Iowa City, IA | BTN |
| Iowa Hawkeyes vs Wisconsin Badgers | Friday, January 7, 2022 | 9:00 PM EST | Kohl Center in Madison, WI | FS1 |
| Indiana Hoosiers vs Iowa Hawkeyes | Friday, January 14, 2022 | 9:00 PM EST | Carver-Hawkeye Arena in Iowa City, IA | FS1 |
| Iowa Hawkeyes vs Minnesota Golden Gophers | Sunday, January 16, 2022 | 7:00 PM EST | Williams Arena in Minneapolis, MN | BTN |
| Iowa Hawkeyes vs Rutgers Scarlet Knights | Thursday, January 20, 2022 | 8:30 PM EST | Rutgers Athletic Center in Piscataway, NJ | BTN |
| Penn State Nittany Lions vs Iowa Hawkeyes | Saturday, January 22, 2022 | 7:00 PM EST | Carver-Hawkeye Arena in Iowa City, IA | BTN |
| Purdue Boilermakers vs Iowa Hawkeyes | Friday, January 28, 2022 | 9:00 PM EST | Carver-Hawkeye Arena in Iowa City, IA | FS1 |
| Iowa Hawkeyes vs Penn State Nittany Lions | Tuesday, February 1, 2022 | 7:00 PM EST | Bryce Jordan Center in University Park, PA | BTN |
| Iowa Hawkeyes vs Ohio State Buckeyes | Friday, February 4, 2022 | 8:00 PM EST | Value City Arena in Columbus, OH | FS1 |
| Minnesota Golden Gophers vs Iowa Hawkeyes | Sunday, February 6, 2022 | 7:00 PM EST | Carver-Hawkeye Arena in Iowa City, IA | ESPN+ |
| Nebraska Cornhuskers vs Iowa Hawkeyes | Sunday, February 13, 2022 | 3:00 PM EST | Carver-Hawkeye Arena in Iowa City, IA | FS1 |
| Michigan State Spartans vs Iowa Hawkeyes | Wednesday, February 23, 2022 | 7:00 PM EST | Carver-Hawkeye Arena in Iowa City, IA | ESPN+ |
| Iowa Hawkeyes vs Nebraska Cornhuskers | Saturday, February 26, 2022 | 9:00 PM EST | Pinnacle Bank Arena in Lincoln, NE | FS1 |
| Iowa Hawkeyes vs Michigan Wolverines | Friday, March 4, 2022 | 9:00 PM EST | Crisler Center in Ann Arbor, MI | FS1 |
