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| Jackson State Tigers vs Illinois Fighting Illini | Wednesday, November 10, 2021 | 8:30 PM EST | State Farm Center in Champaign, IL | BTN |
| Jackson State Tigers vs Louisiana Tech Bulldogs | Friday, November 12, 2021 | 6:30 PM EST | Thomas Assembly Center in Ruston, LA | ESPN+ |
| Jackson State Tigers vs California Baptist Lancers | Wednesday, November 17, 2021 | 10:00 PM EST | CBU Events Center in Riverside, CA | ESPN+ |
| Jackson State Tigers vs Marshall Thundering Herd | Sunday, November 21, 2021 | 7:00 PM EST | Cam Henderson Center in Huntington, WV | ESPN+ |
| Jackson State Tigers vs Indiana Hoosiers | Tuesday, November 23, 2021 | 7:00 PM EST | Simon Skjodt Assembly Hall in Bloomington, IN | ESPN+ |
| Jackson State Tigers vs Louisiana Ragin’ Cajuns | Saturday, November 27, 2021 | 7:00 PM EST | Cajundome in Lafayette, LA | ESPN+ |
| Jackson State Tigers vs Marquette Golden Eagles | Wednesday, December 1, 2021 | 9:00 PM EST | Fiserv Forum in Milwaukee, WI | CBSSN |
| Jackson State Tigers vs Marquette Golden Eagles | Wednesday, December 1, 2021 | 7:00 PM EST | Fiserv Forum in Milwaukee, WI | ESPN+ |
| Jackson State Tigers vs Iowa State Cyclones | Sunday, December 12, 2021 | 7:00 PM EST | James H. Hilton Coliseum in Ames, IA | ESPN+ |
| Jackson State Tigers vs UNI Panthers | Tuesday, December 14, 2021 | 7:00 PM EST | McLeod Center in Cedar Falls, IA | ESPN+ |
| Jackson State Tigers vs Stephen F. Austin Lumberjacks | Tuesday, December 21, 2021 | 7:00 PM EST | William R. Johnson Coliseum in Nacogdoches, TX | ESPN+ |
| Alcorn State Braves vs Jackson State Tigers | Monday, January 3, 2022 | 7:00 PM EST | Lee E. Williams Athletic and Assembly Center in Jackson, MS | ESPN+ |
| Jackson State Tigers vs Alabama State Hornets | Saturday, January 8, 2022 | 5:30 PM EST | Dunn-Oliver Acadome in Montgomery, AL | ESPN+ |
| Jackson State Tigers vs Alabama A&M Bulldogs | Tuesday, January 11, 2022 | 7:30 PM EST | T.M. Elmore Gymnasium in Normal, AL | ESPN+ |
| Prairie View A&M Panthers vs Jackson State Tigers | Saturday, January 15, 2022 | 3:00 PM EST | Lee E. Williams Athletic and Assembly Center in Jackson, MS | ESPN+ |
| Texas Southern Tigers vs Jackson State Tigers | Tuesday, January 18, 2022 | 7:30 PM EST | Lee E. Williams Athletic and Assembly Center in Jackson, MS | ESPN+ |
| Jackson State Tigers vs Bethune-Cookman Wildcats | Saturday, January 22, 2022 | 7:00 PM EST | Moore Gymnasium (Daytona Beach, FL) in Daytona Beach, FL | ESPN+ |
| Jackson State Tigers vs Florida A&M Rattlers | Monday, January 24, 2022 | 7:00 PM EST | Al Lawson Center in Tallahassee, FL | ESPN+ |
| Southern Jaguars vs Jackson State Tigers | Tuesday, February 1, 2022 | 7:30 PM EST | Lee E. Williams Athletic and Assembly Center in Jackson, MS | ESPN+ |
| Jackson State Tigers vs MVSU Delta Devils | Saturday, February 5, 2022 | 5:30 PM EST | Robert W. Harrison HPER Complex in Itta Bena, MS | ESPN+ |
| Jackson State Tigers vs Arkansas-Pine Bluff Golden Lions | Monday, February 7, 2022 | 7:00 PM EST | H. O. Clemmons Arena in Pine Bluff, AR | ESPN+ |
| Florida A&M Rattlers vs Jackson State Tigers | Saturday, February 12, 2022 | 7:00 PM EST | Lee E. Williams Athletic and Assembly Center in Jackson, MS | ESPN+ |
| Bethune-Cookman Wildcats vs Jackson State Tigers | Tuesday, February 15, 2022 | 7:30 PM EST | Lee E. Williams Athletic and Assembly Center in Jackson, MS | ESPN+ |
| Jackson State Tigers vs Alcorn State Braves | Saturday, February 19, 2022 | 7:00 PM EST | Davey L. Whitney Complex in Lorman, MS | ESPN+ |
| Jackson State Tigers vs Texas Southern Tigers | Sunday, February 27, 2022 | 8:00 PM EST | H&PE Arena in Houston, TX | ESPN+ |
| Arkansas-Pine Bluff Golden Lions vs Jackson State Tigers | Thursday, March 3, 2022 | 7:00 PM EST | Lee E. Williams Athletic and Assembly Center in Jackson, MS | ESPN+ |
