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| Lafayette Leopards vs Syracuse Orange | Wednesday, November 10, 2021 | 7:00 PM EST | Carrier Dome in Syracuse, NY | ESPN+ |
| Cornell Big Red vs Lafayette Leopards | Friday, November 12, 2021 | 7:00 PM EST | Kirby Sports Center in Easton, PA | ESPN+ |
| Lafayette Leopards vs Penn Quakers | Tuesday, November 16, 2021 | 7:00 PM EST | The Palestra in Philadelphia, PA | ESPN+ |
| Lafayette Leopards vs Duke Blue Devils | Saturday, November 20, 2021 | 8:00 PM EST | Cameron Indoor Stadium in Durham, NC | ACC Network |
| Lafayette Leopards vs Rutgers Scarlet Knights | Monday, November 22, 2021 | 7:00 PM EST | Rutgers Athletic Center in Piscataway, NJ | ESPN+ |
| Lafayette Leopards vs Columbia Lions | Monday, November 29, 2021 | 7:00 PM EST | Francis S. Levien Gymnasium in New York, NY | ESPN+ |
| Sacred Heart Pioneers vs Lafayette Leopards | Thursday, December 2, 2021 | 7:00 PM EST | Kirby Sports Center in Easton, PA | ESPN+ |
| NJIT Highlanders vs Lafayette Leopards | Sunday, December 5, 2021 | 7:00 PM EST | Kirby Sports Center in Easton, PA | ESPN+ |
| Lafayette Leopards vs Delaware Blue Hens | Wednesday, December 8, 2021 | 7:00 PM EST | Bob Carpenter Center in Newark, DE | ESPN+ |
| Princeton Tigers vs Lafayette Leopards | Saturday, December 11, 2021 | 7:00 PM EST | Kirby Sports Center in Easton, PA | ESPN+ |
| Lafayette Leopards vs Holy Cross Crusaders | Saturday, January 8, 2022 | 7:00 PM EST | Hart Center in Worcester, MA | ESPN+ |
| Navy Midshipmen vs Lafayette Leopards | Monday, January 10, 2022 | 7:00 PM EST | Kirby Sports Center in Easton, PA | ESPN+ |
| Holy Cross Crusaders vs Lafayette Leopards | Wednesday, January 19, 2022 | 7:00 PM EST | Kirby Sports Center in Easton, PA | ESPN+ |
| Lafayette Leopards vs Colgate Raiders | Saturday, January 22, 2022 | 7:00 PM EST | Cotterell Court in Hamilton, NY | ESPN+ |
| Lafayette Leopards vs Navy Midshipmen | Monday, February 7, 2022 | 7:00 PM EST | Alumni Hall (Navy) in Annapolis, MD | ESPN+ |
| Lafayette Leopards vs Lehigh Mountain Hawks | Saturday, February 12, 2022 | 7:00 PM EST | Stabler Arena in Bethlehem, PA | ESPN+ |
| Lehigh Mountain Hawks vs Lafayette Leopards | Saturday, February 26, 2022 | 7:00 PM EST | Kirby Sports Center in Easton, PA | ESPN+ |
