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| Chattanooga Mocs vs Loyola Marymount Lions | Wednesday, November 10, 2021 | 10:00 PM EST | Gersten Pavilion in Los Angeles, CA | ESPN+ |
| Loyola Marymount Lions vs Florida State Seminoles | Sunday, November 21, 2021 | 7:00 PM EST | UNF Arena in Jacksonville, FL | ESPN+ |
| Prairie View A&M Panthers vs Loyola Marymount Lions | Sunday, November 28, 2021 | 8:00 PM EST | Gersten Pavilion in Los Angeles, CA | ESPN+ |
| Grand Canyon Antelopes vs Loyola Marymount Lions | Tuesday, November 30, 2021 | 10:00 PM EST | Gersten Pavilion in Los Angeles, CA | ESPN+ |
| Loyola Marymount Lions vs Tulsa Golden Hurricane | Wednesday, December 8, 2021 | 9:00 PM EST | Donald W. Reynolds Center in Tulsa, OK | ESPNU |
| New Mexico State Aggies vs Loyola Marymount Lions | Sunday, December 12, 2021 | 7:00 PM EST | Gersten Pavilion in Los Angeles, CA | ESPN+ |
| Loyola Marymount Lions vs Nevada Wolf Pack | Saturday, December 18, 2021 | 7:00 PM EST | Lawlor Events Center in Reno, NV | ESPN+ |
| Loyola Marymount Lions vs Bellarmine Knights | Wednesday, December 22, 2021 | 7:00 PM EST | Freedom Hall in Louisville, KY | ESPN+ |
| Portland Pilots vs Loyola Marymount Lions | Thursday, January 6, 2022 | 7:00 PM EST | Gersten Pavilion in Los Angeles, CA | ESPN+ |
| Loyola Marymount Lions vs Pacific Tigers | Saturday, January 8, 2022 | 7:00 PM EST | Alex G. Spanos Center in Stockton, CA | ESPN+ |
| Loyola Marymount Lions vs San Francisco Dons | Thursday, January 13, 2022 | 7:00 PM EST | War Memorial at the Sobrato Center in San Francisco, CA | ESPN+ |
| Pepperdine Waves vs Loyola Marymount Lions | Thursday, January 20, 2022 | 7:00 PM EST | Gersten Pavilion in Los Angeles, CA | ESPN+ |
| St. Mary’s Gaels vs Loyola Marymount Lions | Sunday, January 23, 2022 | 10:00 PM EST | Gersten Pavilion in Los Angeles, CA | ESPNU |
| Loyola Marymount Lions vs Gonzaga Bulldogs | Thursday, January 27, 2022 | 7:00 PM EST | McCarthey Athletic Center in Spokane, WA | ESPN+ |
| Loyola Marymount Lions vs Santa Clara Broncos | Thursday, February 3, 2022 | 7:00 PM EST | Leavey Center in Santa Clara, CA | ESPN+ |
| Loyola Marymount Lions vs St. Mary’s Gaels | Saturday, February 5, 2022 | 7:00 PM EST | University Credit Union Pavilion in Moraga, CA | ESPN+ |
| Loyola Marymount Lions vs Portland Pilots | Saturday, February 12, 2022 | 7:00 PM EST | Chiles Center in Portland, OR | ESPN+ |
| Santa Clara Broncos vs Loyola Marymount Lions | Thursday, February 17, 2022 | 7:00 PM EST | Gersten Pavilion in Los Angeles, CA | ESPN+ |
| Loyola Marymount Lions vs BYU Cougars | Thursday, February 24, 2022 | 7:00 PM EST | Marriott Center in Provo, UT | ESPN+ |
| Pacific Tigers vs Loyola Marymount Lions | Saturday, February 26, 2022 | 7:00 PM EST | Gersten Pavilion in Los Angeles, CA | ESPN+ |
