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| Florida Gulf Coast Eagles vs Loyola Ramblers | Saturday, November 13, 2021 | 7:00 PM EST | Joseph J. Gentile Arena in Chicago, IL | ESPN+ |
| Chicago State Cougars vs Loyola Ramblers | Tuesday, November 16, 2021 | 7:00 PM EST | Joseph J. Gentile Arena in Chicago, IL | ESPN+ |
| Loyola Ramblers vs Michigan State Spartans | Wednesday, November 24, 2021 | 12:00 PM EST | Imperial Arena in Nassau, Bahamas | ESPN |
| Indiana State Sycamores vs Loyola Ramblers | Wednesday, December 1, 2021 | 7:00 PM EST | Joseph J. Gentile Arena in Chicago, IL | ESPN+ |
| Loyola Ramblers vs Vanderbilt Commodores | Friday, December 10, 2021 | 7:00 PM EST | Memorial Gymnasium (Vanderbilt) in Nashville, TN | ESPN+ |
| Norfolk State Spartans vs Loyola Ramblers | Sunday, December 19, 2021 | 7:00 PM EST | Joseph J. Gentile Arena in Chicago, IL | ESPN+ |
| Loyola Ramblers vs Davidson Wildcats | Wednesday, December 22, 2021 | 7:00 PM EST | John M. Belk Arena in Davidson, NC | ESPN+ |
| Loyola Ramblers vs Southern Illinois Salukis | Sunday, January 2, 2022 | 6:00 PM EST | Banterra Center in Carbondale, IL | ESPNU |
| Loyola Ramblers vs Illinois State Redbirds | Wednesday, January 5, 2022 | 7:00 PM EST | Redbird Arena in Normal, IL | ESPN+ |
| Bradley Braves vs Loyola Ramblers | Saturday, January 8, 2022 | 7:00 PM EST | Joseph J. Gentile Arena in Chicago, IL | ESPN+ |
| Valparaiso Crusaders vs Loyola Ramblers | Tuesday, January 11, 2022 | 7:00 PM EST | Joseph J. Gentile Arena in Chicago, IL | ESPN+ |
| Loyola Ramblers vs Indiana State Sycamores | Saturday, January 15, 2022 | 7:00 PM EST | Hulman Center in Terre Haute, IN | ESPN+ |
| Loyola Ramblers vs Evansville Purple Aces | Tuesday, January 18, 2022 | 7:00 PM EST | Ford Center in Evansville, IN | ESPN+ |
| Missouri State Bears vs Loyola Ramblers | Saturday, January 22, 2022 | 7:00 PM EST | Joseph J. Gentile Arena in Chicago, IL | ESPN+ |
| Southern Illinois Salukis vs Loyola Ramblers | Tuesday, January 25, 2022 | 7:00 PM EST | Joseph J. Gentile Arena in Chicago, IL | ESPN+ |
| Loyola Ramblers vs Drake Bulldogs | Sunday, January 30, 2022 | 7:00 PM EST | The Knapp Center in Des Moines, IA | ESPN+ |
| Loyola Ramblers vs Missouri State Bears | Sunday, February 6, 2022 | 2:00 PM EST | JQH Arena in Springfield, MO | ESPNU |
| Loyola Ramblers vs Bradley Braves | Wednesday, February 9, 2022 | 7:00 PM EST | Carver Arena in Peoria, IL | ESPN+ |
| UNI Panthers vs Loyola Ramblers | Sunday, February 13, 2022 | 4:00 PM EST | Joseph J. Gentile Arena in Chicago, IL | ESPN2 |
| Drake Bulldogs vs Loyola Ramblers | Saturday, February 19, 2022 | 6:00 PM EST | Joseph J. Gentile Arena in Chicago, IL | ESPN+ |
| Evansville Purple Aces vs Loyola Ramblers | Wednesday, February 23, 2022 | 7:00 PM EST | Joseph J. Gentile Arena in Chicago, IL | ESPN+ |
| Loyola Ramblers vs UNI Panthers | Saturday, February 26, 2022 | 6:00 PM EST | McLeod Center in Cedar Falls, IA | ESPN+ |
