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| UL Monroe Warhawks vs LSU Tigers | Tuesday, November 9, 2021 | 6:00 PM EST | Pete Maravich Assembly Center in Baton Rouge, LA | ESPN+ |
| Texas State Bobcats vs LSU Tigers | Friday, November 12, 2021 | 6:30 PM EST | Pete Maravich Assembly Center in Baton Rouge, LA | ESPN+ |
| Liberty Flames vs LSU Tigers | Tuesday, November 16, 2021 | 7:00 PM EST | Pete Maravich Assembly Center in Baton Rouge, LA | ESPNU |
| McNeese State Cowboys vs LSU Tigers | Thursday, November 18, 2021 | 6:30 PM EST | Pete Maravich Assembly Center in Baton Rouge, LA | ESPN+ |
| Belmont Bruins vs LSU Tigers | Monday, November 22, 2021 | 7:00 PM EST | Pete Maravich Assembly Center in Baton Rouge, LA | ESPN+ |
| Penn State Nittany Lions vs LSU Tigers | Saturday, November 27, 2021 | 7:00 PM EST | Raider Arena in Destin, FL | ESPN+ |
| Ohio Bobcats vs LSU Tigers | Wednesday, December 1, 2021 | 7:00 PM EST | Pete Maravich Assembly Center in Baton Rouge, LA | ESPN+ |
| LSU Tigers vs Georgia Tech Yellow Jackets | Saturday, December 11, 2021 | 6:00 PM EST | State Farm Arena in Atlanta, GA | ESPN+ |
| Northwestern State Demons vs LSU Tigers | Wednesday, December 15, 2021 | 7:00 PM EST | Pete Maravich Assembly Center in Baton Rouge, LA | SEC Network |
| LSU Tigers vs Louisiana Tech Bulldogs | Saturday, December 18, 2021 | 7:00 PM EST | Brookshire Grocery Arena in Bossier City, LA | ESPN+ |
| Lipscomb Bisons vs LSU Tigers | Thursday, December 23, 2021 | 8:00 PM EST | Pete Maravich Assembly Center in Baton Rouge, LA | SEC Network |
| LSU Tigers vs Auburn Tigers | Thursday, December 30, 2021 | 7:00 PM EST | Auburn Arena in Auburn, AL | ESPNU |
| Kentucky Wildcats vs LSU Tigers | Wednesday, January 5, 2022 | 7:00 PM EST | Pete Maravich Assembly Center in Baton Rouge, LA | ESPN |
| Tennessee Volunteers vs LSU Tigers | Saturday, January 8, 2022 | 6:00 PM EST | Pete Maravich Assembly Center in Baton Rouge, LA | ESPN+ |
| LSU Tigers vs Florida Gators | Thursday, January 13, 2022 | 7:00 PM EST | Exactech Arena at Stephen C. O’Connell Center in Gainesville, FL | ESPN+ |
| Arkansas Razorbacks vs LSU Tigers | Saturday, January 15, 2022 | 7:00 PM EST | Pete Maravich Assembly Center in Baton Rouge, LA | ESPN+ |
| LSU Tigers vs Alabama Crimson Tide | Thursday, January 20, 2022 | 7:00 PM EST | Coleman Coliseum in Tuscaloosa, AL | ESPN2 |
| LSU Tigers vs Tennessee Volunteers | Saturday, January 22, 2022 | 6:00 PM EST | Thompson-Boling Arena in Knoxville, TN | ESPN |
| Texas A&M Aggies vs LSU Tigers | Thursday, January 27, 2022 | 9:00 PM EST | Pete Maravich Assembly Center in Baton Rouge, LA | SEC Network |
| Ole Miss Rebels vs LSU Tigers | Wednesday, February 2, 2022 | 9:00 PM EST | Pete Maravich Assembly Center in Baton Rouge, LA | SEC Network |
| LSU Tigers vs Vanderbilt Commodores | Saturday, February 5, 2022 | 6:00 PM EST | Memorial Gymnasium (Vanderbilt) in Nashville, TN | SEC Network |
| Mississippi State Bulldogs vs LSU Tigers | Sunday, February 13, 2022 | 8:00 PM EST | Pete Maravich Assembly Center in Baton Rouge, LA | ESPN+ |
| LSU Tigers vs South Carolina Gamecocks | Saturday, February 19, 2022 | 3:30 PM EST | Colonial Life Arena in Columbia, SC | SEC Network |
| LSU Tigers vs Kentucky Wildcats | Thursday, February 24, 2022 | 9:00 PM EST | Rupp Arena in Lexington, KY | ESPN+ |
| Missouri Tigers vs LSU Tigers | Sunday, February 27, 2022 | 8:30 PM EST | Pete Maravich Assembly Center in Baton Rouge, LA | SEC Network |
| LSU Tigers vs Arkansas Razorbacks | Thursday, March 3, 2022 | 9:00 PM EST | Bud Walton Arena in Fayetteville, AR | ESPN+ |
