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| Western Kentucky Hilltoppers vs Minnesota Golden Gophers | Friday, November 12, 2021 | 6:30 PM EST | Harrah’s Cherokee Center in Asheville, NC | ESPNU |
| Jacksonville Dolphins vs Minnesota Golden Gophers | Thursday, November 25, 2021 | 9:00 PM EST | Williams Arena in Minneapolis, MN | BTN |
| Minnesota Golden Gophers vs Pittsburgh Panthers | Wednesday, December 1, 2021 | 7:00 PM EST | Petersen Events Center in Pittsburgh, PA | ESPNU |
| Minnesota Golden Gophers vs Mississippi State Bulldogs | Sunday, December 5, 2021 | 2:00 PM EST | Humphrey Coliseum in Starkville, MS | ESPNU |
| Michigan State Spartans vs Minnesota Golden Gophers | Thursday, December 9, 2021 | 9:00 PM EST | Williams Arena in Minneapolis, MN | BTN |
| Minnesota Golden Gophers vs Michigan Wolverines | Saturday, December 11, 2021 | 6:30 PM EST | Crisler Center in Ann Arbor, MI | FOX |
| TAMU Islanders vs Minnesota Golden Gophers | Wednesday, December 15, 2021 | 8:00 PM EST | Williams Arena in Minneapolis, MN | BTN |
| Green Bay Phoenix vs Minnesota Golden Gophers | Wednesday, December 22, 2021 | 7:00 PM EST | Williams Arena in Minneapolis, MN | ESPN+ |
| Alcorn State Braves vs Minnesota Golden Gophers | Wednesday, December 29, 2021 | 7:00 PM EST | Williams Arena in Minneapolis, MN | ESPN+ |
| Illinois Fighting Illini vs Minnesota Golden Gophers | Sunday, January 2, 2022 | 6:00 PM EST | Williams Arena in Minneapolis, MN | BTN |
| Minnesota Golden Gophers vs Indiana Hoosiers | Sunday, January 9, 2022 | 12:00 PM EST | Simon Skjodt Assembly Hall in Bloomington, IN | FS1 |
| Minnesota Golden Gophers vs Michigan State Spartans | Thursday, January 13, 2022 | 7:00 PM EST | Breslin Center in East Lansing, MI | BTN |
| Iowa Hawkeyes vs Minnesota Golden Gophers | Sunday, January 16, 2022 | 7:00 PM EST | Williams Arena in Minneapolis, MN | BTN |
| Minnesota Golden Gophers vs Penn State Nittany Lions | Wednesday, January 19, 2022 | 6:30 PM EST | Bryce Jordan Center in University Park, PA | BTN |
| Rutgers Scarlet Knights vs Minnesota Golden Gophers | Saturday, January 22, 2022 | 12:00 PM EST | Williams Arena in Minneapolis, MN | BTN |
| Ohio State Buckeyes vs Minnesota Golden Gophers | Friday, January 28, 2022 | 7:00 PM EST | Williams Arena in Minneapolis, MN | ESPN2 |
| Minnesota Golden Gophers vs Wisconsin Badgers | Sunday, January 30, 2022 | 1:00 PM EST | Kohl Center in Madison, WI | BTN |
| Minnesota Golden Gophers vs Iowa Hawkeyes | Sunday, February 6, 2022 | 7:00 PM EST | Carver-Hawkeye Arena in Iowa City, IA | ESPN+ |
| Minnesota Golden Gophers vs Nebraska Cornhuskers | Thursday, February 10, 2022 | 9:00 PM EST | Pinnacle Bank Arena in Lincoln, NE | BTN |
| Penn State Nittany Lions vs Minnesota Golden Gophers | Sunday, February 13, 2022 | 8:30 PM EST | Williams Arena in Minneapolis, MN | BTN |
| Minnesota Golden Gophers vs Ohio State Buckeyes | Wednesday, February 16, 2022 | 8:30 PM EST | Value City Arena in Columbus, OH | BTN |
| Northwestern Wildcats vs Minnesota Golden Gophers | Saturday, February 19, 2022 | 4:00 PM EST | Williams Arena in Minneapolis, MN | BTN |
| Wisconsin Badgers vs Minnesota Golden Gophers | Thursday, February 24, 2022 | 9:00 PM EST | Williams Arena in Minneapolis, MN | BTN |
| Minnesota Golden Gophers vs Maryland Terrapins | Thursday, March 3, 2022 | 9:00 PM EST | XFINITY Center in College Park, MD | BTN |
