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| North Alabama Lions vs Mississippi State Bulldogs | Thursday, November 11, 2021 | 8:00 PM EST | Humphrey Coliseum in Starkville, MS | ESPN+ |
| Montana Grizzlies vs Mississippi State Bulldogs | Saturday, November 13, 2021 | 6:30 PM EST | Humphrey Coliseum in Starkville, MS | ESPN+ |
| Detroit Titans vs Mississippi State Bulldogs | Thursday, November 18, 2021 | 8:00 PM EST | Humphrey Coliseum in Starkville, MS | ESPN+ |
| Morehead State Eagles vs Mississippi State Bulldogs | Sunday, November 21, 2021 | 3:00 PM EST | Humphrey Coliseum in Starkville, MS | ESPN+ |
| Louisville Cardinals vs Mississippi State Bulldogs | Friday, November 26, 2021 | 9:30 PM EST | Baha Mar Convention Center in Nassau, Bahamas | ESPN+ |
| Lamar Cardinals vs Mississippi State Bulldogs | Friday, December 3, 2021 | 8:00 PM EST | Humphrey Coliseum in Starkville, MS | ESPN+ |
| Minnesota Golden Gophers vs Mississippi State Bulldogs | Sunday, December 5, 2021 | 2:00 PM EST | Humphrey Coliseum in Starkville, MS | ESPNU |
| Mississippi State Bulldogs vs Colorado State Rams | Saturday, December 11, 2021 | 2:00 PM EST | Dickies Arena in Fort Worth, TX | ESPNU |
| Georgia State Panthers vs Mississippi State Bulldogs | Wednesday, December 15, 2021 | 8:00 PM EST | Humphrey Coliseum in Starkville, MS | ESPN+ |
| Furman Paladins vs Mississippi State Bulldogs | Saturday, December 18, 2021 | 7:00 PM EST | Humphrey Coliseum in Starkville, MS | SEC Network |
| Winthrop Eagles vs Mississippi State Bulldogs | Wednesday, December 22, 2021 | 7:00 PM EST | Mississippi Coliseum in Jackson, MS | ESPN+ |
| Arkansas Razorbacks vs Mississippi State Bulldogs | Thursday, December 30, 2021 | 9:00 PM EST | Humphrey Coliseum in Starkville, MS | SEC Network |
| Mississippi State Bulldogs vs Missouri Tigers | Thursday, January 6, 2022 | 9:00 PM EST | Mizzou Arena in Columbia, MO | SEC Network |
| Mississippi State Bulldogs vs Ole Miss Rebels | Sunday, January 9, 2022 | 8:30 PM EST | The Sandy and John Black Pavilion at Ole Miss in Oxford, MS | SEC Network |
| Georgia Bulldogs vs Mississippi State Bulldogs | Thursday, January 13, 2022 | 7:00 PM EST | Humphrey Coliseum in Starkville, MS | SEC Network |
| Alabama Crimson Tide vs Mississippi State Bulldogs | Saturday, January 15, 2022 | 6:00 PM EST | Humphrey Coliseum in Starkville, MS | SEC Network |
| Mississippi State Bulldogs vs Florida Gators | Wednesday, January 19, 2022 | 6:30 PM EST | Exactech Arena at Stephen C. O’Connell Center in Gainesville, FL | SEC Network |
| Ole Miss Rebels vs Mississippi State Bulldogs | Saturday, January 22, 2022 | 4:00 PM EST | Humphrey Coliseum in Starkville, MS | ESPN+ |
| Mississippi State Bulldogs vs Kentucky Wildcats | Wednesday, January 26, 2022 | 9:00 PM EST | Rupp Arena in Lexington, KY | ESPN |
| South Carolina Gamecocks vs Mississippi State Bulldogs | Wednesday, February 2, 2022 | 7:00 PM EST | Humphrey Coliseum in Starkville, MS | ESPNU |
| Mississippi State Bulldogs vs Arkansas Razorbacks | Sunday, February 6, 2022 | 8:30 PM EST | Bud Walton Arena in Fayetteville, AR | SEC Network |
| Tennessee Volunteers vs Mississippi State Bulldogs | Thursday, February 10, 2022 | 9:00 PM EST | Humphrey Coliseum in Starkville, MS | ESPN+ |
| Mississippi State Bulldogs vs LSU Tigers | Sunday, February 13, 2022 | 8:00 PM EST | Pete Maravich Assembly Center in Baton Rouge, LA | ESPN+ |
| Missouri Tigers vs Mississippi State Bulldogs | Sunday, February 20, 2022 | 8:30 PM EST | Humphrey Coliseum in Starkville, MS | SEC Network |
| Mississippi State Bulldogs vs South Carolina Gamecocks | Wednesday, February 23, 2022 | 6:30 PM EST | Colonial Life Arena in Columbia, SC | SEC Network |
| Vanderbilt Commodores vs Mississippi State Bulldogs | Saturday, February 26, 2022 | 1:00 PM EST | Humphrey Coliseum in Starkville, MS | SEC Network |
| Auburn Tigers vs Mississippi State Bulldogs | Thursday, March 3, 2022 | 9:00 PM EST | Humphrey Coliseum in Starkville, MS | SEC Network |
