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| Bethune-Cookman Wildcats vs MTSU Blue Raiders | Friday, November 12, 2021 | 7:00 PM EST | Murphy Center in Murfreesboro, TN | ESPN+ |
| Winthrop Eagles vs MTSU Blue Raiders | Tuesday, November 16, 2021 | 6:30 PM EST | Murphy Center in Murfreesboro, TN | ESPN+ |
| MTSU Blue Raiders vs Stephen F. Austin Lumberjacks | Saturday, November 20, 2021 | 8:00 PM EST | William R. Johnson Coliseum in Nacogdoches, TX | ESPN+ |
| Rider Broncs vs MTSU Blue Raiders | Tuesday, November 23, 2021 | 12:30 PM EST | Hard Rock Hotel Riviera Maya in Cancun, Mexico | ESPN+ |
| UT Martin Skyhawks vs MTSU Blue Raiders | Wednesday, December 1, 2021 | 7:00 PM EST | Murphy Center in Murfreesboro, TN | ESPN+ |
| MTSU Blue Raiders vs UT Martin Skyhawks | Saturday, December 11, 2021 | 7:00 PM EST | Skyhawk Arena in Martin, TN | ESPN+ |
| MTSU Blue Raiders vs Ole Miss Rebels | Thursday, December 16, 2021 | 7:30 PM EST | The Sandy and John Black Pavilion at Ole Miss in Oxford, MS | ESPN+ |
| Coastal Carolina Chanticleers vs MTSU Blue Raiders | Sunday, December 19, 2021 | 7:00 PM EST | Murphy Center in Murfreesboro, TN | ESPN+ |
| MTSU Blue Raiders vs Chattanooga Mocs | Wednesday, December 22, 2021 | 7:00 PM EST | McKenzie Arena in Chattanooga, TN | ESPN+ |
| UTSA Roadrunners vs MTSU Blue Raiders | Thursday, December 30, 2021 | 7:00 PM EST | Murphy Center in Murfreesboro, TN | ESPN+ |
| MTSU Blue Raiders vs Rice Owls | Thursday, January 6, 2022 | 7:00 PM EST | Tudor Fieldhouse in Houston, TX | ESPN+ |
| MTSU Blue Raiders vs North Texas Mean Green | Saturday, January 8, 2022 | 7:00 PM EST | UNT Coliseum in Denton, TX | ESPN+ |
| Florida Atlantic Owls vs MTSU Blue Raiders | Thursday, January 13, 2022 | 7:00 PM EST | Murphy Center in Murfreesboro, TN | ESPN+ |
| FIU Panthers vs MTSU Blue Raiders | Saturday, January 15, 2022 | 7:00 PM EST | Murphy Center in Murfreesboro, TN | ESPN+ |
| Southern Miss Golden Eagles vs MTSU Blue Raiders | Saturday, January 22, 2022 | 7:00 PM EST | Murphy Center in Murfreesboro, TN | ESPN+ |
| MTSU Blue Raiders vs Marshall Thundering Herd | Thursday, January 27, 2022 | 7:00 PM EST | Cam Henderson Center in Huntington, WV | ESPN+ |
| MTSU Blue Raiders vs UAB Blazers | Saturday, February 5, 2022 | 7:00 PM EST | Bartow Arena in Birmingham, AL | ESPN+ |
| Charlotte 49ers vs MTSU Blue Raiders | Sunday, February 13, 2022 | 7:00 PM EST | Murphy Center in Murfreesboro, TN | ESPN+ |
| MTSU Blue Raiders vs FIU Panthers | Thursday, February 17, 2022 | 7:00 PM EST | Ocean Bank Convocation Center in Miami, FL | ESPN+ |
| MTSU Blue Raiders vs Florida Atlantic Owls | Saturday, February 19, 2022 | 4:00 PM EST | FAU Arena in Boca Raton, FL | ESPN+ |
| Marshall Thundering Herd vs MTSU Blue Raiders | Thursday, February 24, 2022 | 7:00 PM EST | Murphy Center in Murfreesboro, TN | ESPN+ |
| Western Kentucky Hilltoppers vs MTSU Blue Raiders | Saturday, February 26, 2022 | 7:00 PM EST | Murphy Center in Murfreesboro, TN | ESPN+ |
| MTSU Blue Raiders vs Charlotte 49ers | Wednesday, March 2, 2022 | 7:00 PM EST | Dale F. Halton Arena in Charlotte, NC | ESPN+ |
