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| New Hampshire Wildcats vs Marquette Golden Eagles | Saturday, November 13, 2021 | 8:30 PM EST | Fiserv Forum in Milwaukee, WI | FS2 |
| New Hampshire Wildcats vs Providence Friars | Thursday, November 18, 2021 | 6:30 PM EST | Dunkin Donuts Center in Providence, RI | FS2 |
| Quinnipiac Bobcats vs New Hampshire Wildcats | Wednesday, November 24, 2021 | 7:00 PM EST | Lundholm Gymnasium in Durham, NH | ESPN+ |
| New Hampshire Wildcats vs Holy Cross Crusaders | Saturday, November 27, 2021 | 2:00 PM EST | Hart Center in Worcester, MA | ESPN+ |
| New Hampshire Wildcats vs Bryant Bulldogs | Wednesday, December 8, 2021 | 7:00 PM EST | Chace Athletic Center in Smithfield, RI | ESPN+ |
| New Hampshire Wildcats vs Duquesne Dukes | Saturday, December 11, 2021 | 1:00 PM EST | UPMC Cooper Fieldhouse in Pittsburgh, PA | ESPN+ |
| New Hampshire Wildcats vs VCU Rams | Tuesday, December 21, 2021 | 7:00 PM EST | Stuart C. Siegel Center in Richmond, VA | ESPN+ |
| New Hampshire Wildcats vs Dartmouth Big Green | Wednesday, December 29, 2021 | 7:00 PM EST | Edward Leede Arena in Hanover, NH | ESPN+ |
| UMBC Retrievers vs New Hampshire Wildcats | Sunday, January 2, 2022 | 7:00 PM EST | Lundholm Gymnasium in Durham, NH | ESPN+ |
| New Hampshire Wildcats vs Vermont Catamounts | Wednesday, January 5, 2022 | 7:00 PM EST | Patrick Gymnasium in Burlington, VT | ESPN+ |
| Albany Great Danes vs New Hampshire Wildcats | Saturday, January 8, 2022 | 7:00 PM EST | Lundholm Gymnasium in Durham, NH | ESPN+ |
| Maine Black Bears vs New Hampshire Wildcats | Wednesday, January 12, 2022 | 7:00 PM EST | Lundholm Gymnasium in Durham, NH | ESPN+ |
| New Hampshire Wildcats vs Stony Brook Seawolves | Saturday, January 15, 2022 | 7:00 PM EST | Island FCU Arena in Stony Brook, NY | ESPN+ |
| New Hampshire Wildcats vs Hartford Hawks | Thursday, January 20, 2022 | 7:00 PM EST | Chase Arena in West Hartford, CT | ESPN+ |
| UMass Lowell River Hawks vs New Hampshire Wildcats | Saturday, January 22, 2022 | 7:00 PM EST | Lundholm Gymnasium in Durham, NH | ESPN+ |
| New Hampshire Wildcats vs Maine Black Bears | Wednesday, January 26, 2022 | 7:00 PM EST | Cross Insurance Center in Bangor, ME | ESPN+ |
| New Hampshire Wildcats vs UMBC Retrievers | Saturday, February 5, 2022 | 7:00 PM EST | UMBC Event Center in Baltimore, MD | ESPN+ |
| NJIT Highlanders vs New Hampshire Wildcats | Wednesday, February 9, 2022 | 7:00 PM EST | Lundholm Gymnasium in Durham, NH | ESPN+ |
| New Hampshire Wildcats vs Binghamton Bearcats | Saturday, February 12, 2022 | 2:00 PM EST | Events Center (Binghamton) in Binghamton, NY | ESPN+ |
| New Hampshire Wildcats vs Albany Great Danes | Saturday, February 19, 2022 | 7:00 PM EST | SEFCU Arena in Albany, NY | ESPN+ |
| New Hampshire Wildcats vs NJIT Highlanders | Thursday, February 24, 2022 | 7:00 PM EST | NJIT Wellness and Events Center in Newark, NJ | ESPN+ |
| Binghamton Bearcats vs New Hampshire Wildcats | Saturday, February 26, 2022 | 7:00 PM EST | Lundholm Gymnasium in Durham, NH | ESPN+ |
| New Hampshire Wildcats vs UMass Lowell River Hawks | Tuesday, March 1, 2022 | 7:00 PM EST | Costello Athletic Center in Lowell, MA | ESPN+ |
