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| Niagara Purple Eagles vs Xavier Musketeers | Wednesday, November 10, 2021 | 7:30 PM EST | Cintas Center in Cincinnati, OH | ESPN+ |
| Niagara Purple Eagles vs Ohio State Buckeyes | Friday, November 12, 2021 | 7:00 PM EST | Value City Arena in Columbus, OH | ESPN+ |
| Niagara Purple Eagles vs Youngstown State Penguins | Sunday, November 21, 2021 | 7:00 PM EST | Beeghly Center in Youngstown, OH | ESPN+ |
| Niagara Purple Eagles vs Colgate Raiders | Tuesday, November 30, 2021 | 7:00 PM EST | Cotterell Court in Hamilton, NY | ESPN+ |
| Monmouth Hawks vs Niagara Purple Eagles | Friday, December 3, 2021 | 7:00 PM EST | Gallagher Center in Niagara Falls, NY | ESPN+ |
| Fairfield Stags vs Niagara Purple Eagles | Sunday, December 5, 2021 | 7:00 PM EST | Gallagher Center in Niagara Falls, NY | ESPN+ |
| Niagara Purple Eagles vs Eastern Michigan Eagles | Wednesday, December 8, 2021 | 7:00 PM EST | Convocation Center (MI) in Ypsilanti, MI | ESPN+ |
| Niagara Purple Eagles vs Albany Great Danes | Saturday, December 18, 2021 | 7:00 PM EST | KeyBank Center in Buffalo, NY | ESPN+ |
| Niagara Purple Eagles vs Binghamton Bearcats | Wednesday, December 22, 2021 | 7:00 PM EST | Events Center (Binghamton) in Binghamton, NY | ESPN+ |
| Niagara Purple Eagles vs Manhattan Jaspers | Sunday, January 2, 2022 | 7:00 PM EST | Draddy Gymnasium in Riverdale, NY | ESPN+ |
| Quinnipiac Bobcats vs Niagara Purple Eagles | Sunday, January 9, 2022 | 1:00 PM EST | Gallagher Center in Niagara Falls, NY | ESPN+ |
| Niagara Purple Eagles vs Iona Gaels | Sunday, January 16, 2022 | 7:00 PM EST | Hynes Athletics Center in New Rochelle, NY | ESPN+ |
| St. Peter’s Peacocks vs Niagara Purple Eagles | Friday, January 21, 2022 | 7:00 PM EST | Gallagher Center in Niagara Falls, NY | ESPN+ |
| Rider Broncs vs Niagara Purple Eagles | Sunday, January 23, 2022 | 7:00 PM EST | Gallagher Center in Niagara Falls, NY | ESPN+ |
| Niagara Purple Eagles vs Siena Saints | Friday, January 28, 2022 | 7:00 PM EST | Times Union Center in Albany, NY | ESPN+ |
| Niagara Purple Eagles vs Monmouth Hawks | Sunday, January 30, 2022 | 7:00 PM EST | OceanFirst Bank Center in West Long Branch, NJ | ESPN+ |
| Manhattan Jaspers vs Niagara Purple Eagles | Friday, February 4, 2022 | 7:00 PM EST | Gallagher Center in Niagara Falls, NY | ESPN+ |
| Iona Gaels vs Niagara Purple Eagles | Sunday, February 6, 2022 | 7:00 PM EST | Gallagher Center in Niagara Falls, NY | ESPN+ |
| Niagara Purple Eagles vs Fairfield Stags | Saturday, February 12, 2022 | 7:00 PM EST | Webster Bank Arena in Bridgeport, CT | ESPN+ |
| Niagara Purple Eagles vs Marist Red Foxes | Tuesday, February 15, 2022 | 7:00 PM EST | McCann Arena in Poughkeepsie, NY | ESPN+ |
| Niagara Purple Eagles vs Canisius Golden Griffins | Saturday, February 19, 2022 | 7:00 PM EST | Koessler Athletic Center in Buffalo, NY | ESPN+ |
| Niagara Purple Eagles vs Rider Broncs | Friday, February 25, 2022 | 7:00 PM EST | Alumni Gymnasium (Rider) in Lawrenceville, NJ | ESPN+ |
| Siena Saints vs Niagara Purple Eagles | Thursday, March 3, 2022 | 7:00 PM EST | Gallagher Center in Niagara Falls, NY | ESPN+ |
