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| William & Mary Tribe vs Norfolk State Spartans | Wednesday, November 17, 2021 | 7:00 PM EST | Joseph G. Echols Hall in Norfolk, VA | ESPN+ |
| Norfolk State Spartans vs Bowling Green Falcons | Friday, November 19, 2021 | 7:00 PM EST | Stroh Center in Bowling Green, OH | ESPN+ |
| Norfolk State Spartans vs Xavier Musketeers | Sunday, November 21, 2021 | 12:00 PM EST | Cintas Center in Cincinnati, OH | FS1 |
| Norfolk State Spartans vs Grambling Tigers | Monday, November 29, 2021 | 6:00 PM EST | Footprint Center in Phoenix, AZ | ESPNU |
| Hampton Pirates vs Norfolk State Spartans | Monday, November 29, 2021 | 8:00 PM EST | Footprint Center in Phoenix, AZ | ESPN2 |
| Norfolk State Spartans vs UNC Wilmington Seahawks | Thursday, December 2, 2021 | 7:00 PM EST | Trask Coliseum in Wilmington, NC | ESPN+ |
| Norfolk State Spartans vs Wichita State Shockers | Sunday, December 12, 2021 | 7:00 PM EST | Charles Koch Arena in Wichita, KS | ESPN+ |
| Norfolk State Spartans vs Loyola Ramblers | Sunday, December 19, 2021 | 7:00 PM EST | Joseph J. Gentile Arena in Chicago, IL | ESPN+ |
| Norfolk State Spartans vs New Mexico Lobos | Tuesday, December 21, 2021 | 7:00 PM EST | Dreamstyle Arena in Albuquerque, NM | ESPN+ |
| Norfolk State Spartans vs Campbell Fighting Camels | Thursday, December 30, 2021 | 7:30 PM EST | John W. Pope Jr. Convocation Center in Buies Creek, NC | ESPN+ |
| Norfolk State Spartans vs Howard Bison | Saturday, January 15, 2022 | 4:00 PM EST | Burr Gymnasium in Washington, DC | ESPN+ |
| Morgan State Bears vs Norfolk State Spartans | Tuesday, January 25, 2022 | 7:30 PM EST | Joseph G. Echols Hall in Norfolk, VA | ESPN+ |
| Norfolk State Spartans vs North Carolina Central Eagles | Tuesday, February 1, 2022 | 7:30 PM EST | McDougald-McLendon Arena in Durham, NC | ESPN+ |
| Norfolk State Spartans vs Morgan State Bears | Tuesday, February 22, 2022 | 7:30 PM EST | Hill Field House in Baltimore, MD | ESPN+ |
| South Carolina State Bulldogs vs Norfolk State Spartans | Saturday, February 26, 2022 | 6:00 PM EST | Joseph G. Echols Hall in Norfolk, VA | ESPN+ |
| Howard Bison vs Norfolk State Spartans | Friday, March 4, 2022 | 7:30 PM EST | Joseph G. Echols Hall in Norfolk, VA | ESPN+ |
