|
| Brown Bears vs North Carolina Tar Heels | Friday, November 12, 2021 | 9:00 PM EST | Dean E. Smith Center in Chapel Hill, NC | ESPN+ |
| North Carolina Tar Heels vs Charleston Cougars | Tuesday, November 16, 2021 | 7:00 PM EST | TD Arena in Charleston, SC | ESPN+ |
| UNC Asheville Bulldogs vs North Carolina Tar Heels | Tuesday, November 23, 2021 | 7:00 PM EST | Dean E. Smith Center in Chapel Hill, NC | ESPN+ |
| Michigan Wolverines vs North Carolina Tar Heels | Thursday, December 2, 2021 | 9:15 PM EST | Dean E. Smith Center in Chapel Hill, NC | ESPN |
| North Carolina Tar Heels vs Georgia Tech Yellow Jackets | Sunday, December 5, 2021 | 3:00 PM EST | McCamish Pavilion in Atlanta, GA | ESPN2 |
| Elon Phoenix vs North Carolina Tar Heels | Sunday, December 12, 2021 | 8:00 PM EST | Dean E. Smith Center in Chapel Hill, NC | ACC Network |
| Furman Paladins vs North Carolina Tar Heels | Wednesday, December 15, 2021 | 7:00 PM EST | Dean E. Smith Center in Chapel Hill, NC | ESPN2 |
| UCLA Bruins vs North Carolina Tar Heels | Saturday, December 18, 2021 | 3:00 PM EST | T-Mobile Arena in Las Vegas, NV | CBS |
| Appalachian State Mountaineers vs North Carolina Tar Heels | Wednesday, December 22, 2021 | 7:00 PM EST | Dean E. Smith Center in Chapel Hill, NC | ACC Network |
| Virginia Tech Hokies vs North Carolina Tar Heels | Thursday, December 30, 2021 | 7:00 PM EST | Dean E. Smith Center in Chapel Hill, NC | ESPN2 |
| North Carolina Tar Heels vs Notre Dame Fighting Irish | Thursday, January 6, 2022 | 9:00 PM EST | Purcell Pavilion in South Bend, IN | ESPN2 |
| Virginia Cavaliers vs North Carolina Tar Heels | Saturday, January 8, 2022 | 1:00 PM EST | Dean E. Smith Center in Chapel Hill, NC | ESPN |
| Georgia Tech Yellow Jackets vs North Carolina Tar Heels | Sunday, January 16, 2022 | 8:00 PM EST | Dean E. Smith Center in Chapel Hill, NC | ACC Network |
| North Carolina Tar Heels vs Miami Hurricanes | Tuesday, January 18, 2022 | 7:00 PM EST | Watsco Center in Coral Gables, FL | ESPN |
| North Carolina Tar Heels vs Wake Forest Demon Deacons | Sunday, January 23, 2022 | 8:00 PM EST | Lawrence Joel Veterans Memorial Coliseum in Winston-Salem, NC | ACC Network |
| Boston College Eagles vs North Carolina Tar Heels | Thursday, January 27, 2022 | 7:00 PM EST | Dean E. Smith Center in Chapel Hill, NC | ACC Network Extra |
| North Carolina Tar Heels vs Louisville Cardinals | Tuesday, February 1, 2022 | 7:00 PM EST | KFC Yum! Center in Louisville, KY | ESPN |
| Duke Blue Devils vs North Carolina Tar Heels | Saturday, February 5, 2022 | 6:00 PM EST | Dean E. Smith Center in Chapel Hill, NC | ESPN |
| Florida State Seminoles vs North Carolina Tar Heels | Saturday, February 12, 2022 | 2:00 PM EST | Dean E. Smith Center in Chapel Hill, NC | ESPN+ |
| North Carolina Tar Heels vs Virginia Tech Hokies | Saturday, February 19, 2022 | 4:00 PM EST | Cassell Coliseum in Blacksburg, VA | ESPN+ |
| Louisville Cardinals vs North Carolina Tar Heels | Tuesday, February 22, 2022 | 7:00 PM EST | Dean E. Smith Center in Chapel Hill, NC | ESPN |
| North Carolina Tar Heels vs NC State Wolfpack | Saturday, February 26, 2022 | 7:00 PM EST | PNC Arena in Raleigh, NC | ESPN+ |
