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| Northern Illinois Huskies vs Washington Huskies | Wednesday, November 10, 2021 | 10:00 PM EST | Alaska Airlines Arena in Seattle, WA | PAC12 |
| Northern Illinois Huskies vs Indiana Hoosiers | Friday, November 12, 2021 | 7:00 PM EST | Simon Skjodt Assembly Hall in Bloomington, IN | ESPN+ |
| Northern Illinois Huskies vs Missouri Tigers | Thursday, November 18, 2021 | 7:00 PM EST | Mizzou Arena in Columbia, MO | ESPN+ |
| Northern Illinois Huskies vs Marquette Golden Eagles | Sunday, November 28, 2021 | 8:00 PM EST | Fiserv Forum in Milwaukee, WI | FS2 |
| Eastern Illinois Panthers vs Northern Illinois Huskies | Wednesday, December 1, 2021 | 7:00 PM EST | NIU Convocation Center in Dekalb, IL | ESPN+ |
| Northern Illinois Huskies vs Chicago State Cougars | Monday, December 13, 2021 | 7:00 PM EST | Jones Convocation Center in Chicago, IL | ESPN+ |
| Northern Illinois Huskies vs UIC Flames | Sunday, December 19, 2021 | 7:00 PM EST | Credit Union 1 Arena in Chicago, IL | ESPN+ |
| Indiana State Sycamores vs Northern Illinois Huskies | Wednesday, December 22, 2021 | 7:00 PM EST | NIU Convocation Center in Dekalb, IL | ESPN+ |
| Ball State Cardinals vs Northern Illinois Huskies | Tuesday, December 28, 2021 | 7:00 PM EST | NIU Convocation Center in Dekalb, IL | ESPN+ |
| Buffalo Bulls vs Northern Illinois Huskies | Tuesday, January 4, 2022 | 7:00 PM EST | NIU Convocation Center in Dekalb, IL | ESPN+ |
| Northern Illinois Huskies vs Toledo Rockets | Saturday, January 8, 2022 | 7:00 PM EST | Savage Arena in Toledo, OH | ESPN+ |
| Northern Illinois Huskies vs Kent State Golden Flashes | Tuesday, January 11, 2022 | 7:00 PM EST | M.A.C. Center in Kent, OH | ESPN+ |
| Northern Illinois Huskies vs Eastern Michigan Eagles | Saturday, January 15, 2022 | 7:00 PM EST | Convocation Center (MI) in Ypsilanti, MI | ESPN+ |
| Bowling Green Falcons vs Northern Illinois Huskies | Tuesday, January 18, 2022 | 7:00 PM EST | NIU Convocation Center in Dekalb, IL | ESPN+ |
| Northern Illinois Huskies vs Miami RedHawks | Saturday, January 22, 2022 | 7:00 PM EST | Millett Hall in Oxford, OH | ESPN+ |
| Northern Illinois Huskies vs Ohio Bobcats | Tuesday, January 25, 2022 | 7:00 PM EST | Convocation Center (OH) in Athens, OH | ESPN+ |
| Northern Illinois Huskies vs Western Michigan Broncos | Tuesday, February 1, 2022 | 7:00 PM EST | University Arena (MI) in Kalamazoo, MI | ESPN+ |
| Northern Illinois Huskies vs Bowling Green Falcons | Saturday, February 5, 2022 | 7:00 PM EST | Stroh Center in Bowling Green, OH | ESPN+ |
| Toledo Rockets vs Northern Illinois Huskies | Saturday, February 12, 2022 | 7:00 PM EST | NIU Convocation Center in Dekalb, IL | ESPN+ |
| Northern Illinois Huskies vs Ball State Cardinals | Tuesday, February 15, 2022 | 7:00 PM EST | Worthen Arena in Muncie, IN | ESPN+ |
| Miami RedHawks vs Northern Illinois Huskies | Saturday, February 19, 2022 | 7:00 PM EST | NIU Convocation Center in Dekalb, IL | ESPN+ |
| Northern Illinois Huskies vs Eastern Michigan Eagles | Wednesday, February 23, 2022 | 7:00 PM EST | Convocation Center (MI) in Ypsilanti, MI | ESPN+ |
| Northern Illinois Huskies vs Buffalo Bulls | Saturday, February 26, 2022 | 7:00 PM EST | Alumni Arena in Buffalo, NY | ESPN+ |
| Kent State Golden Flashes vs Northern Illinois Huskies | Tuesday, March 1, 2022 | 7:00 PM EST | NIU Convocation Center in Dekalb, IL | ESPN+ |
| Ohio Bobcats vs Northern Illinois Huskies | Friday, March 4, 2022 | 7:00 PM EST | NIU Convocation Center in Dekalb, IL | ESPN+ |
