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| Northwestern State Demons vs Oklahoma Sooners | Tuesday, November 9, 2021 | 6:30 PM EST | Lloyd Noble Center in Norman, OK | ESPN+ |
| Northwestern State Demons vs Tulsa Golden Hurricane | Wednesday, November 10, 2021 | 7:30 PM EST | Donald W. Reynolds Center in Tulsa, OK | ESPN+ |
| Northwestern State Demons vs SMU Mustangs | Monday, November 15, 2021 | 6:30 PM EST | Moody Coliseum in Dallas, TX | ESPN+ |
| Louisiana Tech Bulldogs vs Northwestern State Demons | Saturday, November 20, 2021 | 8:30 PM EST | Prather Coliseum in Natchitoches, LA | ESPN+ |
| Northwestern State Demons vs UL Monroe Warhawks | Monday, November 22, 2021 | 3:00 PM EST | Fant-Ewing Coliseum in Monroe, LA | ESPN+ |
| Stephen F. Austin Lumberjacks vs Northwestern State Demons | Sunday, November 28, 2021 | 4:00 PM EST | Prather Coliseum in Natchitoches, LA | ESPN+ |
| Northwestern State Demons vs Houston Cougars | Tuesday, November 30, 2021 | 7:00 PM EST | Fertitta Center in Houston, TX | ESPN+ |
| Northwestern State Demons vs LSU Tigers | Wednesday, December 15, 2021 | 7:00 PM EST | Pete Maravich Assembly Center in Baton Rouge, LA | SEC Network |
| Northwestern State Demons vs Texas A&M Aggies | Tuesday, December 21, 2021 | 7:00 PM EST | Reed Arena in College Station, TX | ESPN+ |
| Northwestern State Demons vs Baylor Bears | Tuesday, December 28, 2021 | 7:00 PM EST | Ferrell Center in Waco, TX | ESPN+ |
| Northwestern State Demons vs SE Louisiana Lions | Saturday, January 15, 2022 | 7:00 PM EST | University Center (LA) in Hammond, LA | ESPN+ |
| Northwestern State Demons vs New Orleans Privateers | Saturday, January 22, 2022 | 5:00 PM EST | Lakefront Arena in New Orleans, LA | ESPN+ |
| Incarnate Word Cardinals vs Northwestern State Demons | Friday, January 28, 2022 | 8:30 PM EST | Prather Coliseum in Natchitoches, LA | ESPN+ |
| Northwestern State Demons vs Houston Baptist Huskies | Thursday, February 3, 2022 | 7:00 PM EST | Sharp Gymnasium in Houston, TX | ESPN+ |
| Northwestern State Demons vs McNeese State Cowboys | Saturday, February 5, 2022 | 4:00 PM EST | Burton Coliseum in Lake Charles, LA | ESPN+ |
| McNeese State Cowboys vs Northwestern State Demons | Saturday, February 12, 2022 | 4:00 PM EST | Prather Coliseum in Natchitoches, LA | ESPN+ |
| Northwestern State Demons vs Incarnate Word Cardinals | Thursday, February 17, 2022 | 7:00 PM EST | Alice P. McDermott Convocation Center in San Antonio, TX | ESPN+ |
| Northwestern State Demons vs TAMU Islanders | Saturday, February 19, 2022 | 4:30 PM EST | American Bank Center in Corpus Christi, TX | ESPN+ |
| New Orleans Privateers vs Northwestern State Demons | Saturday, February 26, 2022 | 4:00 PM EST | Prather Coliseum in Natchitoches, LA | ESPN+ |
