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| Youngstown State Penguins vs Penn State Nittany Lions | Thursday, November 11, 2021 | 8:30 PM EST | Bryce Jordan Center in University Park, PA | BTN |
| Penn State Nittany Lions vs UMass Minutemen | Monday, November 15, 2021 | 7:00 PM EST | William D. Mullins Memorial Center in Amherst, MA | ESPN+ |
| St. Francis Brooklyn Terriers vs Penn State Nittany Lions | Thursday, November 18, 2021 | 7:00 PM EST | Bryce Jordan Center in University Park, PA | ESPN+ |
| Cornell Big Red vs Penn State Nittany Lions | Monday, November 22, 2021 | 6:30 PM EST | Bryce Jordan Center in University Park, PA | BTN |
| Penn State Nittany Lions vs LSU Tigers | Saturday, November 27, 2021 | 7:00 PM EST | Raider Arena in Destin, FL | ESPN+ |
| Miami Hurricanes vs Penn State Nittany Lions | Thursday, December 2, 2021 | 9:15 PM EST | Bryce Jordan Center in University Park, PA | ESPNU |
| Ohio State Buckeyes vs Penn State Nittany Lions | Monday, December 6, 2021 | 7:30 PM EST | Bryce Jordan Center in University Park, PA | BTN |
| Wagner Seahawks vs Penn State Nittany Lions | Wednesday, December 8, 2021 | 7:00 PM EST | Bryce Jordan Center in University Park, PA | ESPN+ |
| Penn State Nittany Lions vs Michigan State Spartans | Saturday, December 11, 2021 | 2:00 PM EST | Breslin Center in East Lansing, MI | BTN |
| Penn State Nittany Lions vs VCU Rams | Saturday, December 18, 2021 | 7:00 PM EST | Stuart C. Siegel Center in Richmond, VA | ESPN+ |
| Quinnipiac Bobcats vs Penn State Nittany Lions | Thursday, December 23, 2021 | 7:00 PM EST | Bryce Jordan Center in University Park, PA | ESPN+ |
| Indiana Hoosiers vs Penn State Nittany Lions | Sunday, January 2, 2022 | 4:00 PM EST | Bryce Jordan Center in University Park, PA | BTN |
| Penn State Nittany Lions vs Northwestern Wildcats | Thursday, January 6, 2022 | 9:00 PM EST | Welsh-Ryan Arena in Evanston, IL | BTN |
| Purdue Boilermakers vs Penn State Nittany Lions | Saturday, January 8, 2022 | 12:00 PM EST | Bryce Jordan Center in University Park, PA | BTN |
| Rutgers Scarlet Knights vs Penn State Nittany Lions | Tuesday, January 11, 2022 | 6:30 PM EST | Bryce Jordan Center in University Park, PA | BTN |
| Penn State Nittany Lions vs Ohio State Buckeyes | Sunday, January 16, 2022 | 7:00 PM EST | Value City Arena in Columbus, OH | BTN |
| Minnesota Golden Gophers vs Penn State Nittany Lions | Wednesday, January 19, 2022 | 6:30 PM EST | Bryce Jordan Center in University Park, PA | BTN |
| Penn State Nittany Lions vs Iowa Hawkeyes | Saturday, January 22, 2022 | 7:00 PM EST | Carver-Hawkeye Arena in Iowa City, IA | BTN |
| Penn State Nittany Lions vs Indiana Hoosiers | Thursday, January 27, 2022 | 8:30 PM EST | Simon Skjodt Assembly Hall in Bloomington, IN | BTN |
| Iowa Hawkeyes vs Penn State Nittany Lions | Tuesday, February 1, 2022 | 7:00 PM EST | Bryce Jordan Center in University Park, PA | BTN |
| Penn State Nittany Lions vs Wisconsin Badgers | Saturday, February 5, 2022 | 6:00 PM EST | Kohl Center in Madison, WI | BTN |
| Penn State Nittany Lions vs Minnesota Golden Gophers | Sunday, February 13, 2022 | 8:30 PM EST | Williams Arena in Minneapolis, MN | BTN |
| Michigan State Spartans vs Penn State Nittany Lions | Tuesday, February 15, 2022 | 6:30 PM EST | Bryce Jordan Center in University Park, PA | BTN |
| Penn State Nittany Lions vs Maryland Terrapins | Tuesday, February 22, 2022 | 7:00 PM EST | XFINITY Center in College Park, MD | ESPN2 |
| Northwestern Wildcats vs Penn State Nittany Lions | Saturday, February 26, 2022 | 7:00 PM EST | Bryce Jordan Center in University Park, PA | FS1 |
| Penn State Nittany Lions vs Illinois Fighting Illini | Friday, March 4, 2022 | 7:00 PM EST | State Farm Center in Champaign, IL | FOX |
