|
| Citadel Bulldogs vs Pittsburgh Panthers | Tuesday, November 9, 2021 | 6:45 PM EST | Petersen Events Center in Pittsburgh, PA | ESPN+ |
| Pittsburgh Panthers vs West Virginia Mountaineers | Saturday, November 13, 2021 | 8:30 PM EST | WVU Coliseum in Morgantown, WV | ESPNU |
| UNC Wilmington Seahawks vs Pittsburgh Panthers | Tuesday, November 16, 2021 | 7:00 PM EST | Petersen Events Center in Pittsburgh, PA | ESPN+ |
| Towson Tigers vs Pittsburgh Panthers | Friday, November 19, 2021 | 6:00 PM EST | Petersen Events Center in Pittsburgh, PA | ACC Network |
| Vanderbilt Commodores vs Pittsburgh Panthers | Thursday, November 25, 2021 | 9:00 PM EST | Petersen Events Center in Pittsburgh, PA | ACC Network |
| UMBC Retrievers vs Pittsburgh Panthers | Saturday, November 27, 2021 | 7:00 PM EST | Petersen Events Center in Pittsburgh, PA | ESPN+ |
| Minnesota Golden Gophers vs Pittsburgh Panthers | Wednesday, December 1, 2021 | 7:00 PM EST | Petersen Events Center in Pittsburgh, PA | ESPNU |
| Pittsburgh Panthers vs Virginia Cavaliers | Saturday, December 4, 2021 | 8:00 PM EST | John Paul Jones Arena in Charlottesville, VA | ACC Network |
| Colgate Raiders vs Pittsburgh Panthers | Friday, December 10, 2021 | 8:00 PM EST | Petersen Events Center in Pittsburgh, PA | ACC Network |
| Monmouth Hawks vs Pittsburgh Panthers | Monday, December 13, 2021 | 7:00 PM EST | Petersen Events Center in Pittsburgh, PA | ACC Network |
| Pittsburgh Panthers vs St. John’s Red Storm | Saturday, December 18, 2021 | 7:00 PM EST | Madison Square Garden in New York, NY | ESPN+ |
| Jacksonville Dolphins vs Pittsburgh Panthers | Tuesday, December 21, 2021 | 7:00 PM EST | Petersen Events Center in Pittsburgh, PA | ESPN+ |
| Notre Dame Fighting Irish vs Pittsburgh Panthers | Wednesday, December 29, 2021 | 8:00 PM EST | Petersen Events Center in Pittsburgh, PA | ACC Network |
| Pittsburgh Panthers vs Louisville Cardinals | Thursday, January 6, 2022 | 7:00 PM EST | KFC Yum! Center in Louisville, KY | ESPN+ |
| Boston College Eagles vs Pittsburgh Panthers | Saturday, January 8, 2022 | 4:00 PM EST | Petersen Events Center in Pittsburgh, PA | ACC Network |
| Pittsburgh Panthers vs Syracuse Orange | Wednesday, January 12, 2022 | 7:00 PM EST | Carrier Dome in Syracuse, NY | ESPNU |
| Louisville Cardinals vs Pittsburgh Panthers | Saturday, January 15, 2022 | 4:00 PM EST | Petersen Events Center in Pittsburgh, PA | ACC Network |
| Virginia Cavaliers vs Pittsburgh Panthers | Thursday, January 20, 2022 | 9:00 PM EST | Petersen Events Center in Pittsburgh, PA | ACC Network |
| Pittsburgh Panthers vs Clemson Tigers | Saturday, January 22, 2022 | 6:00 PM EST | Littlejohn Coliseum in Clemson, SC | ACC Network |
| Syracuse Orange vs Pittsburgh Panthers | Wednesday, January 26, 2022 | 8:00 PM EST | Petersen Events Center in Pittsburgh, PA | ACC Network |
| Virginia Tech Hokies vs Pittsburgh Panthers | Sunday, February 6, 2022 | 7:00 PM EST | Petersen Events Center in Pittsburgh, PA | ACC Network |
| Pittsburgh Panthers vs Florida State Seminoles | Thursday, February 10, 2022 | 9:00 PM EST | Donald L. Tucker Center in Tallahassee, FL | ACC Network |
| NC State Wolfpack vs Pittsburgh Panthers | Saturday, February 12, 2022 | 3:00 PM EST | Petersen Events Center in Pittsburgh, PA | ACC Network |
| Georgia Tech Yellow Jackets vs Pittsburgh Panthers | Sunday, February 20, 2022 | 7:00 PM EST | Petersen Events Center in Pittsburgh, PA | ACC Network |
| Miami Hurricanes vs Pittsburgh Panthers | Wednesday, February 23, 2022 | 8:00 PM EST | Petersen Events Center in Pittsburgh, PA | ACC Network |
| Duke Blue Devils vs Pittsburgh Panthers | Wednesday, March 2, 2022 | 8:00 PM EST | Petersen Events Center in Pittsburgh, PA | ACC Network |
