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| Portland Pilots vs Arizona State Sun Devils | Wednesday, November 10, 2021 | 7:00 PM EST | Desert Financial Arena in Tempe, AZ | PAC12 |
| Arkansas-Pine Bluff Golden Lions vs Portland Pilots | Friday, November 19, 2021 | 7:00 PM EST | Chiles Center in Portland, OR | ESPN+ |
| Portland Pilots vs Portland State Vikings | Tuesday, November 23, 2021 | 7:00 PM EST | Viking Pavilion in Portland, OR | ESPN+ |
| Portland Pilots vs Montana State Bobcats | Friday, November 26, 2021 | 3:00 PM EST | Worthington Arena in Bozeman, MT | ESPN+ |
| Portland Pilots vs Incarnate Word Cardinals | Sunday, November 28, 2021 | 2:00 PM EST | Alice P. McDermott Convocation Center in San Antonio, TX | ESPN+ |
| VMI Keydets vs Portland Pilots | Saturday, December 4, 2021 | 7:00 PM EST | Chiles Center in Portland, OR | ESPN+ |
| Cal Poly Mustangs vs Portland Pilots | Tuesday, December 14, 2021 | 10:00 PM EST | Chiles Center in Portland, OR | ESPN+ |
| Portland Pilots vs Oregon Ducks | Thursday, December 16, 2021 | 9:00 PM EST | Matthew Knight Arena in Eugene, OR | PAC12 |
| San Jose State Spartans vs Portland Pilots | Saturday, December 18, 2021 | 7:00 PM EST | Chiles Center in Portland, OR | ESPN+ |
| Portland Pilots vs Montana State Bobcats | Sunday, December 19, 2021 | 7:00 PM EST | Worthington Arena in Bozeman, MT | ESPN+ |
| Portland Pilots vs UC Davis Aggies | Wednesday, December 22, 2021 | 7:00 PM EST | The Pavilion (UC Davis) in Davis, CA | ESPN+ |
| Portland Pilots vs Loyola Marymount Lions | Thursday, January 6, 2022 | 7:00 PM EST | Gersten Pavilion in Los Angeles, CA | ESPN+ |
| Santa Clara Broncos vs Portland Pilots | Saturday, January 8, 2022 | 7:00 PM EST | Chiles Center in Portland, OR | ESPN+ |
| Portland Pilots vs Pepperdine Waves | Saturday, January 15, 2022 | 7:00 PM EST | Firestone Fieldhouse in Malibu, CA | ESPN+ |
| San Francisco Dons vs Portland Pilots | Thursday, January 20, 2022 | 7:00 PM EST | Chiles Center in Portland, OR | ESPN+ |
| Portland Pilots vs BYU Cougars | Saturday, January 22, 2022 | 7:00 PM EST | Marriott Center in Provo, UT | ESPN+ |
| Pacific Tigers vs Portland Pilots | Thursday, January 27, 2022 | 7:00 PM EST | Chiles Center in Portland, OR | ESPN+ |
| St. Mary’s Gaels vs Portland Pilots | Thursday, February 3, 2022 | 7:00 PM EST | Chiles Center in Portland, OR | ESPN+ |
| Portland Pilots vs San Francisco Dons | Saturday, February 5, 2022 | 7:00 PM EST | War Memorial at the Sobrato Center in San Francisco, CA | ESPN+ |
| Loyola Marymount Lions vs Portland Pilots | Saturday, February 12, 2022 | 7:00 PM EST | Chiles Center in Portland, OR | ESPN+ |
| Pepperdine Waves vs Portland Pilots | Saturday, February 19, 2022 | 7:00 PM EST | Chiles Center in Portland, OR | ESPN+ |
| Portland Pilots vs Pacific Tigers | Thursday, February 24, 2022 | 7:00 PM EST | Alex G. Spanos Center in Stockton, CA | ESPN+ |
| Portland Pilots vs Santa Clara Broncos | Saturday, February 26, 2022 | 7:00 PM EST | Leavey Center in Santa Clara, CA | ESPN+ |
