|
| Pepperdine Waves vs Rice Owls | Wednesday, November 10, 2021 | 8:00 PM EST | Tudor Fieldhouse in Houston, TX | ESPN+ |
| Rice Owls vs Houston Cougars | Friday, November 12, 2021 | 7:00 PM EST | Fertitta Center in Houston, TX | ESPN+ |
| Southern Jaguars vs Rice Owls | Wednesday, November 17, 2021 | 7:00 PM EST | Tudor Fieldhouse in Houston, TX | ESPN+ |
| Rice Owls vs New Orleans Privateers | Saturday, November 20, 2021 | 8:00 PM EST | Lakefront Arena in New Orleans, LA | ESPN+ |
| Rice Owls vs Evansville Purple Aces | Monday, November 22, 2021 | 11:00 AM EST | Hertz Arena in Estero, FL | ESPN+ |
| Texas State Bobcats vs Rice Owls | Wednesday, December 1, 2021 | 8:00 PM EST | Tudor Fieldhouse in Houston, TX | ESPN+ |
| Rice Owls vs Houston Baptist Huskies | Sunday, December 12, 2021 | 8:00 PM EST | Sharp Gymnasium in Houston, TX | ESPN+ |
| Rice Owls vs Texas Longhorns | Wednesday, December 22, 2021 | 7:00 PM EST | Frank Erwin Center in Austin, TX | ESPN+ |
| MTSU Blue Raiders vs Rice Owls | Thursday, January 6, 2022 | 7:00 PM EST | Tudor Fieldhouse in Houston, TX | ESPN+ |
| UAB Blazers vs Rice Owls | Saturday, January 8, 2022 | 7:00 PM EST | Tudor Fieldhouse in Houston, TX | ESPN+ |
| Rice Owls vs Western Kentucky Hilltoppers | Thursday, January 13, 2022 | 7:00 PM EST | E. A. Diddle Arena in Bowling Green, KY | ESPN+ |
| Rice Owls vs Marshall Thundering Herd | Saturday, January 15, 2022 | 7:00 PM EST | Cam Henderson Center in Huntington, WV | ESPN+ |
| Old Dominion Monarchs vs Rice Owls | Thursday, January 20, 2022 | 7:00 PM EST | Tudor Fieldhouse in Houston, TX | ESPN+ |
| Charlotte 49ers vs Rice Owls | Saturday, January 22, 2022 | 7:00 PM EST | Tudor Fieldhouse in Houston, TX | ESPN+ |
| Rice Owls vs Louisiana Tech Bulldogs | Thursday, January 27, 2022 | 7:00 PM EST | Thomas Assembly Center in Ruston, LA | ESPN+ |
| UTSA Roadrunners vs Rice Owls | Thursday, February 3, 2022 | 7:00 PM EST | Tudor Fieldhouse in Houston, TX | ESPN+ |
| UTEP Miners vs Rice Owls | Saturday, February 5, 2022 | 7:00 PM EST | Tudor Fieldhouse in Houston, TX | ESPN+ |
| North Texas Mean Green vs Rice Owls | Saturday, February 12, 2022 | 7:00 PM EST | Tudor Fieldhouse in Houston, TX | ESPN+ |
| Rice Owls vs UAB Blazers | Thursday, February 17, 2022 | 7:00 PM EST | Bartow Arena in Birmingham, AL | ESPN+ |
| Rice Owls vs FIU Panthers | Saturday, February 19, 2022 | 7:00 PM EST | Ocean Bank Convocation Center in Miami, FL | ESPN+ |
| Louisiana Tech Bulldogs vs Rice Owls | Thursday, February 24, 2022 | 7:00 PM EST | Tudor Fieldhouse in Houston, TX | ESPN+ |
| Southern Miss Golden Eagles vs Rice Owls | Saturday, February 26, 2022 | 7:00 PM EST | Tudor Fieldhouse in Houston, TX | ESPN+ |
| Rice Owls vs UTEP Miners | Thursday, March 3, 2022 | 7:00 PM EST | Don Haskins Center in El Paso, TX | ESPN+ |
