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| Fairleigh Dickinson Knights vs Seton Hall Pirates | Thursday, November 11, 2021 | 7:00 PM EST | Prudential Center in Newark, NJ | FS1 |
| Yale Bulldogs vs Seton Hall Pirates | Sunday, November 14, 2021 | 12:00 PM EST | Prudential Center in Newark, NJ | FS1 |
| Seton Hall Pirates vs Michigan Wolverines | Wednesday, November 17, 2021 | 9:00 PM EST | Crisler Center in Ann Arbor, MI | FS1 |
| Ohio State Buckeyes vs Seton Hall Pirates | Monday, November 22, 2021 | 6:00 PM EST | Suncoast Credit Union Arena in Fort Myers, FL | FS1 |
| Bethune-Cookman Wildcats vs Seton Hall Pirates | Sunday, November 28, 2021 | 12:00 PM EST | Prudential Center in Newark, NJ | FS1 |
| Wagner Seahawks vs Seton Hall Pirates | Thursday, December 2, 2021 | 7:00 PM EST | Prudential Center in Newark, NJ | FS2 |
| Texas Longhorns vs Seton Hall Pirates | Thursday, December 9, 2021 | 6:30 PM EST | Prudential Center in Newark, NJ | FS1 |
| Rutgers Scarlet Knights vs Seton Hall Pirates | Monday, December 13, 2021 | 7:30 PM EST | Prudential Center in Newark, NJ | FS1 |
| Iona Gaels vs Seton Hall Pirates | Saturday, December 18, 2021 | 7:00 PM EST | Madison Square Garden in New York, NY | ESPN+ |
| St. John’s Red Storm vs Seton Hall Pirates | Tuesday, December 21, 2021 | 8:30 PM EST | Prudential Center in Newark, NJ | FS1 |
| Seton Hall Pirates vs DePaul Blue Demons | Friday, December 24, 2021 | 8:30 PM EST | Wintrust Arena in Chicago, IL | FS1 |
| Seton Hall Pirates vs Providence Friars | Thursday, December 30, 2021 | 7:00 PM EST | Dunkin Donuts Center in Providence, RI | FS1 |
| Seton Hall Pirates vs Butler Bulldogs | Wednesday, January 5, 2022 | 8:00 PM EST | Hinkle Fieldhouse in Indianapolis, IN | CBSSN |
| Connecticut Huskies vs Seton Hall Pirates | Saturday, January 8, 2022 | 12:00 PM EST | Prudential Center in Newark, NJ | FOX |
| Seton Hall Pirates vs Marquette Golden Eagles | Saturday, January 15, 2022 | 12:00 PM EST | Fiserv Forum in Milwaukee, WI | FS1 |
| Providence Friars vs Seton Hall Pirates | Tuesday, January 18, 2022 | 7:00 PM EST | Prudential Center in Newark, NJ | FS1 |
| Seton Hall Pirates vs St. John’s Red Storm | Saturday, January 22, 2022 | 12:00 PM EST | Madison Square Garden in New York, NY | FS1 |
| Marquette Golden Eagles vs Seton Hall Pirates | Wednesday, January 26, 2022 | 5:00 PM EST | Prudential Center in Newark, NJ | FS1 |
| Seton Hall Pirates vs Georgetown Hoyas | Wednesday, February 2, 2022 | 8:30 PM EST | Capital One Arena in Washington, DC | FS1 |
| Creighton Bluejays vs Seton Hall Pirates | Saturday, February 5, 2022 | 7:00 PM EST | Prudential Center in Newark, NJ | FS1 |
| Xavier Musketeers vs Seton Hall Pirates | Thursday, February 10, 2022 | 7:00 PM EST | Prudential Center in Newark, NJ | FS1 |
| Seton Hall Pirates vs Villanova Wildcats | Saturday, February 12, 2022 | 1:00 PM EST | Wells Fargo Center in Philadelphia, PA | FOX |
| DePaul Blue Demons vs Seton Hall Pirates | Sunday, February 20, 2022 | 8:00 PM EST | Prudential Center in Newark, NJ | FS1 |
| Butler Bulldogs vs Seton Hall Pirates | Thursday, February 24, 2022 | 8:30 PM EST | Prudential Center in Newark, NJ | FS1 |
| Seton Hall Pirates vs Xavier Musketeers | Saturday, February 26, 2022 | 3:30 PM EST | Cintas Center in Cincinnati, OH | FOX |
| Georgetown Hoyas vs Seton Hall Pirates | Thursday, March 3, 2022 | 7:00 PM EST | Prudential Center in Newark, NJ | CBSSN |
