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| South Alabama Jaguars vs Wichita State Shockers | Saturday, November 13, 2021 | 4:00 PM EST | Charles Koch Arena in Wichita, KS | ESPN+ |
| South Alabama Jaguars vs Alabama Crimson Tide | Tuesday, November 16, 2021 | 6:30 PM EST | Coleman Coliseum in Tuscaloosa, AL | ESPN+ |
| Southern Miss Golden Eagles vs South Alabama Jaguars | Wednesday, December 1, 2021 | 8:00 PM EST | Mitchell Center in Mobile, AL | ESPN+ |
| SIU Edwardsville Cougars vs South Alabama Jaguars | Wednesday, December 22, 2021 | 8:00 PM EST | Mitchell Center in Mobile, AL | ESPN+ |
| South Alabama Jaguars vs UT Arlington Mavericks | Friday, December 31, 2021 | 8:00 PM EST | College Park Center in Arlington, TX | ESPN+ |
| Appalachian State Mountaineers vs South Alabama Jaguars | Friday, January 7, 2022 | 8:00 PM EST | Mitchell Center in Mobile, AL | ESPN+ |
| Coastal Carolina Chanticleers vs South Alabama Jaguars | Saturday, January 8, 2022 | 4:00 PM EST | Mitchell Center in Mobile, AL | ESPN+ |
| Georgia State Panthers vs South Alabama Jaguars | Friday, January 14, 2022 | 8:00 PM EST | Mitchell Center in Mobile, AL | ESPN+ |
| Georgia Southern Eagles vs South Alabama Jaguars | Sunday, January 16, 2022 | 7:00 PM EST | Mitchell Center in Mobile, AL | ESPN+ |
| South Alabama Jaguars vs Louisiana Ragin’ Cajuns | Thursday, January 20, 2022 | 7:00 PM EST | Cajundome in Lafayette, LA | ESPN+ |
| South Alabama Jaguars vs UL Monroe Warhawks | Saturday, January 22, 2022 | 3:00 PM EST | Fant-Ewing Coliseum in Monroe, LA | ESPN+ |
| Troy Trojans vs South Alabama Jaguars | Friday, January 28, 2022 | 8:00 PM EST | Mitchell Center in Mobile, AL | ESPN+ |
| South Alabama Jaguars vs Georgia Southern Eagles | Thursday, February 3, 2022 | 7:00 PM EST | W.S. Hanner Fieldhouse in Statesboro, GA | ESPN+ |
| South Alabama Jaguars vs Georgia State Panthers | Saturday, February 5, 2022 | 3:00 PM EST | GSU Sports Arena in Atlanta, GA | ESPN+ |
| Arkansas State Red Wolves vs South Alabama Jaguars | Sunday, February 13, 2022 | 7:00 PM EST | Mitchell Center in Mobile, AL | ESPN+ |
| South Alabama Jaguars vs Appalachian State Mountaineers | Saturday, February 19, 2022 | 7:00 PM EST | Holmes Convocation Center in Boone, NC | ESPN+ |
| Texas State Bobcats vs South Alabama Jaguars | Friday, February 25, 2022 | 8:00 PM EST | Mitchell Center in Mobile, AL | ESPN+ |
| UT Arlington Mavericks vs South Alabama Jaguars | Saturday, February 26, 2022 | 4:00 PM EST | Mitchell Center in Mobile, AL | ESPN+ |
