You can live stream all Southampton games for the 2021-22 EPL season at fuboTV by clicking here.
| Game | Date | Time | Stadium | TV Station |
|---|---|---|---|---|
| Everton vs Southampton | Saturday, August 14, 2021 | 10:00 AM EST | Goodison Park in Liverpool, England | USA Network |
| Southampton vs Manchester United | Sunday, August 22, 2021 | 9:00 AM EST | St. Mary’s Stadium in Southampton, England | Peacock Premium |
| Newcastle United vs Southampton | Saturday, August 28, 2021 | 10:00 AM EST | St. James’ Park in Tyne, England | Peacock Premium |
| Southampton vs West Ham United | Saturday, September 11, 2021 | 10:00 AM EST | St. Mary’s Stadium in Southampton, England | Peacock Premium |
| Manchester City vs Southampton | Saturday, September 18, 2021 | 10:00 AM EST | Etihad Stadium in Manchester, England | USA Network |
| Southampton vs Wolverhampton | Sunday, September 26, 2021 | 9:00 AM EST | St. Mary’s Stadium in Southampton, England | NBCSN |
| Chelsea vs Southampton | Saturday, October 2, 2021 | 10:00 AM EST | Stamford Bridge in London, England | USA Network |
| Southampton vs Leeds United | Saturday, October 16, 2021 | 10:00 AM EST | St. Mary’s Stadium in Southampton, England | USA Network |
| Southampton vs Burnley | Saturday, October 23, 2021 | 10:00 AM EST | St. Mary’s Stadium in Southampton, England | Peacock Premium |
| Watford vs Southampton | Saturday, October 30, 2021 | 10:00 AM EST | Vicarage Road in Hertfordshire, England | NBCSN |
| Southampton vs Aston Villa | Friday, November 5, 2021 | 4:00 PM EST | St. Mary’s Stadium in Southampton, England | NBCSN |
| Norwich City vs Southampton | Saturday, November 20, 2021 | 10:00 AM EST | Carrow Road in Norfolk, England | Peacock Premium |
| Liverpool vs Southampton | Saturday, November 27, 2021 | 10:00 AM EST | Anfield in Liverpool, England | NBC |
| Southampton vs Leicester City | Wednesday, December 1, 2021 | 2:45 PM EST | St. Mary’s Stadium in Southampton, England | Peacock Premium |
| Southampton vs Brighton | Saturday, December 4, 2021 | 10:00 AM EST | St. Mary’s Stadium in Southampton, England | Peacock Premium |
| Arsenal vs Southampton | Saturday, December 11, 2021 | 10:00 AM EST | Emirates Stadium in London, England | CNBC |
| Crystal Palace vs Southampton | Tuesday, December 14, 2021 | 3:00 PM EST | Selhurst Park in London, England | Peacock Premium |
| Southampton vs Brentford | Saturday, December 18, 2021 | 10:00 AM EST | St. Mary’s Stadium in Southampton, England | NBC |
| West Ham United vs Southampton | Sunday, December 26, 2021 | 10:00 AM EST | London Stadium in London, England | NBCSN |
| Southampton vs Tottenham | Tuesday, December 28, 2021 | 10:00 AM EST | St. Mary’s Stadium in Southampton, England | NBCSN |
| Southampton vs Newcastle United | Saturday, January 1, 2022 | 10:00 AM EST | St. Mary’s Stadium in Southampton, England | USA Network |
| Wolverhampton vs Southampton | Saturday, January 15, 2022 | 10:00 AM EST | Molineux Stadium in West Midlands, England | NBCSN |
| Southampton vs Manchester City | Saturday, January 22, 2022 | 10:00 AM EST | St. Mary’s Stadium in Southampton, England | NBCSN |
| Tottenham vs Southampton | Wednesday, February 9, 2022 | 2:45 PM EST | Tottenham Hotspur Stadium in London, England | Peacock Premium |
| Manchester United vs Southampton | Saturday, February 12, 2022 | 10:00 AM EST | Old Trafford in Manchester, England | NBCSN |
| Southampton vs Everton | Saturday, February 19, 2022 | 10:00 AM EST | St. Mary’s Stadium in Southampton, England | Peacock Premium |
| Southampton vs Norwich City | Saturday, February 26, 2022 | 10:00 AM EST | St. Mary’s Stadium in Southampton, England | NBCSN |
| Aston Villa vs Southampton | Saturday, March 5, 2022 | 10:00 AM EST | Villa Park in Birmingham, England | NBCSN |
| Southampton vs Watford | Saturday, March 12, 2022 | 10:00 AM EST | St. Mary’s Stadium in Southampton, England | NBCSN |
| Burnley vs Southampton | Saturday, March 19, 2022 | 11:00 AM EST | Turf Moor in Lancashire, England | NBCSN |
| Leeds United vs Southampton | Saturday, April 2, 2022 | 10:00 AM EST | Elland Road in Leeds, England | Peacock Premium |
| Southampton vs Chelsea | Saturday, April 9, 2022 | 10:00 AM EST | St. Mary’s Stadium in Southampton, England | Peacock Premium |
| Southampton vs Arsenal | Saturday, April 16, 2022 | 10:00 AM EST | St. Mary’s Stadium in Southampton, England | Peacock Premium |
| Brighton vs Southampton | Saturday, April 23, 2022 | 10:00 AM EST | The American Express Community Stadium in Brighton and Hove, Sussex | NBCSN |
| Southampton vs Crystal Palace | Saturday, April 30, 2022 | 10:00 AM EST | St. Mary’s Stadium in Southampton, England | NBCSN |
| Brentford vs Southampton | Saturday, May 7, 2022 | 10:00 AM EST | Brentford Community Stadium in London, England | NBCSN |
| Southampton vs Liverpool | Sunday, May 15, 2022 | 10:00 AM EST | St. Mary’s Stadium in Southampton, England | NBCSN |
| Leicester City vs Southampton | Sunday, May 22, 2022 | 11:00 AM EST | King Power Stadium in Leicester, England | USA Network |