|
| Louisiana Ragin’ Cajuns vs Southern Miss Golden Eagles | Friday, November 12, 2021 | 7:00 PM EST | Reed Green Coliseum in Hattiesburg, MS | ESPN+ |
| Southern Miss Golden Eagles vs TCU Horned Frogs | Tuesday, November 16, 2021 | 8:00 PM EST | Ed and Rae Schollmaier Arena in Fort Worth, TX | ESPN+ |
| Lamar Cardinals vs Southern Miss Golden Eagles | Sunday, November 21, 2021 | 7:00 PM EST | Reed Green Coliseum in Hattiesburg, MS | ESPN+ |
| Southern Miss Golden Eagles vs UNC Wilmington Seahawks | Wednesday, November 24, 2021 | 7:00 PM EST | Dahlberg Arena in Missoula, MT | ESPN+ |
| San Diego Toreros vs Southern Miss Golden Eagles | Thursday, November 25, 2021 | 6:00 PM EST | Dahlberg Arena in Missoula, MT | ESPN+ |
| Southern Miss Golden Eagles vs Montana Grizzlies | Friday, November 26, 2021 | 7:00 PM EST | Dahlberg Arena in Missoula, MT | ESPN+ |
| Southern Miss Golden Eagles vs South Alabama Jaguars | Wednesday, December 1, 2021 | 8:00 PM EST | Mitchell Center in Mobile, AL | ESPN+ |
| Jacksonville Dolphins vs Southern Miss Golden Eagles | Tuesday, December 14, 2021 | 7:00 PM EST | Reed Green Coliseum in Hattiesburg, MS | ESPN+ |
| Southern Miss Golden Eagles vs UL Monroe Warhawks | Saturday, December 18, 2021 | 7:00 PM EST | Fant-Ewing Coliseum in Monroe, LA | ESPN+ |
| Southern Miss Golden Eagles vs East Carolina Pirates | Tuesday, December 21, 2021 | 7:00 PM EST | Williams Arena at Minges Coliseum in Greenville, NC | ESPN+ |
| Western Kentucky Hilltoppers vs Southern Miss Golden Eagles | Thursday, December 30, 2021 | 7:00 PM EST | Reed Green Coliseum in Hattiesburg, MS | ESPN+ |
| Southern Miss Golden Eagles vs UTSA Roadrunners | Thursday, January 6, 2022 | 7:00 PM EST | UTSA Convocation Center in San Antonio, TX | ESPN+ |
| Southern Miss Golden Eagles vs UTEP Miners | Saturday, January 8, 2022 | 7:00 PM EST | Don Haskins Center in El Paso, TX | ESPN+ |
| Southern Miss Golden Eagles vs Louisiana Tech Bulldogs | Thursday, January 13, 2022 | 7:00 PM EST | Thomas Assembly Center in Ruston, LA | ESPN+ |
| Louisiana Tech Bulldogs vs Southern Miss Golden Eagles | Sunday, January 16, 2022 | 7:00 PM EST | Reed Green Coliseum in Hattiesburg, MS | ESPN+ |
| Southern Miss Golden Eagles vs MTSU Blue Raiders | Saturday, January 22, 2022 | 7:00 PM EST | Murphy Center in Murfreesboro, TN | ESPN+ |
| North Texas Mean Green vs Southern Miss Golden Eagles | Thursday, January 27, 2022 | 7:00 PM EST | Reed Green Coliseum in Hattiesburg, MS | ESPN+ |
| Southern Miss Golden Eagles vs FIU Panthers | Thursday, February 3, 2022 | 7:00 PM EST | Ocean Bank Convocation Center in Miami, FL | ESPN+ |
| Southern Miss Golden Eagles vs Florida Atlantic Owls | Saturday, February 5, 2022 | 4:00 PM EST | FAU Arena in Boca Raton, FL | ESPN+ |
| UTSA Roadrunners vs Southern Miss Golden Eagles | Thursday, February 17, 2022 | 7:00 PM EST | Reed Green Coliseum in Hattiesburg, MS | ESPN+ |
| UTEP Miners vs Southern Miss Golden Eagles | Saturday, February 19, 2022 | 7:00 PM EST | Reed Green Coliseum in Hattiesburg, MS | ESPN+ |
| Southern Miss Golden Eagles vs North Texas Mean Green | Thursday, February 24, 2022 | 7:00 PM EST | UNT Coliseum in Denton, TX | ESPN+ |
| Southern Miss Golden Eagles vs Rice Owls | Saturday, February 26, 2022 | 7:00 PM EST | Tudor Fieldhouse in Houston, TX | ESPN+ |
| UAB Blazers vs Southern Miss Golden Eagles | Wednesday, March 2, 2022 | 7:00 PM EST | Reed Green Coliseum in Hattiesburg, MS | ESPN+ |
