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| Stony Brook Seawolves vs George Mason Patriots | Tuesday, November 9, 2021 | 4:30 PM EST | EagleBank Arena in Fairfax, VA | ESPN+ |
| Stony Brook Seawolves vs Kansas Jayhawks | Thursday, November 18, 2021 | 7:00 PM EST | Allen Fieldhouse in Lawrence, KS | ESPN+ |
| Sacred Heart Pioneers vs Stony Brook Seawolves | Monday, November 22, 2021 | 7:00 PM EST | Island FCU Arena in Stony Brook, NY | ESPN+ |
| Stony Brook Seawolves vs Fairfield Stags | Wednesday, November 24, 2021 | 7:00 PM EST | Webster Bank Arena in Bridgeport, CT | ESPN+ |
| Stony Brook Seawolves vs Yale Bulldogs | Sunday, November 28, 2021 | 7:00 PM EST | John J. Lee Amphitheater in New Haven, CT | ESPN+ |
| Hofstra Pride vs Stony Brook Seawolves | Thursday, December 9, 2021 | 7:00 PM EST | Island FCU Arena in Stony Brook, NY | ESPN+ |
| Bryant Bulldogs vs Stony Brook Seawolves | Saturday, December 11, 2021 | 7:00 PM EST | Island FCU Arena in Stony Brook, NY | ESPN+ |
| Central Connecticut Blue Devils vs Stony Brook Seawolves | Tuesday, December 14, 2021 | 7:00 PM EST | Island FCU Arena in Stony Brook, NY | ESPN+ |
| St. Peter’s Peacocks vs Stony Brook Seawolves | Saturday, December 18, 2021 | 7:00 PM EST | Island FCU Arena in Stony Brook, NY | ESPN+ |
| Stony Brook Seawolves vs Florida Gators | Wednesday, December 22, 2021 | 7:00 PM EST | Exactech Arena at Stephen C. O’Connell Center in Gainesville, FL | ESPN+ |
| Stony Brook Seawolves vs Hartford Hawks | Sunday, January 2, 2022 | 2:00 PM EST | Chase Arena in West Hartford, CT | ESPN+ |
| UMBC Retrievers vs Stony Brook Seawolves | Wednesday, January 5, 2022 | 7:00 PM EST | Island FCU Arena in Stony Brook, NY | ESPN+ |
| Maine Black Bears vs Stony Brook Seawolves | Saturday, January 8, 2022 | 7:00 PM EST | Island FCU Arena in Stony Brook, NY | ESPN+ |
| Stony Brook Seawolves vs Vermont Catamounts | Wednesday, January 12, 2022 | 7:00 PM EST | Patrick Gymnasium in Burlington, VT | ESPN+ |
| New Hampshire Wildcats vs Stony Brook Seawolves | Saturday, January 15, 2022 | 7:00 PM EST | Island FCU Arena in Stony Brook, NY | ESPN+ |
| Stony Brook Seawolves vs Binghamton Bearcats | Thursday, January 20, 2022 | 7:00 PM EST | Events Center (Binghamton) in Binghamton, NY | ESPN+ |
| Stony Brook Seawolves vs Albany Great Danes | Saturday, January 22, 2022 | 7:00 PM EST | SEFCU Arena in Albany, NY | ESPN+ |
| Vermont Catamounts vs Stony Brook Seawolves | Wednesday, January 26, 2022 | 7:00 PM EST | Island FCU Arena in Stony Brook, NY | ESPN+ |
| Stony Brook Seawolves vs NJIT Highlanders | Sunday, February 6, 2022 | 7:00 PM EST | NJIT Wellness and Events Center in Newark, NJ | ESPN+ |
| UMass Lowell River Hawks vs Stony Brook Seawolves | Wednesday, February 9, 2022 | 7:00 PM EST | Island FCU Arena in Stony Brook, NY | ESPN+ |
| Stony Brook Seawolves vs Maine Black Bears | Sunday, February 13, 2022 | 1:00 PM EST | Cross Insurance Center in Bangor, ME | ESPN+ |
| Hartford Hawks vs Stony Brook Seawolves | Saturday, February 19, 2022 | 7:00 PM EST | Island FCU Arena in Stony Brook, NY | ESPN+ |
| Stony Brook Seawolves vs UMass Lowell River Hawks | Wednesday, February 23, 2022 | 7:00 PM EST | Costello Athletic Center in Lowell, MA | ESPN+ |
| Albany Great Danes vs Stony Brook Seawolves | Saturday, February 26, 2022 | 7:00 PM EST | Island FCU Arena in Stony Brook, NY | ESPN+ |
| NJIT Highlanders vs Stony Brook Seawolves | Tuesday, March 1, 2022 | 7:00 PM EST | Island FCU Arena in Stony Brook, NY | ESPN+ |
